Phenotypes associated with this allele

• Allele Symbol: Rr156^tm6.1Cog
• Allele Name: targeted mutation 6.1, Michel Cogne
• Allele ID: MGI:4838169
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr156^tm6.1Cog/Rr156^tm6.1Cog	involves: 129P2/OlaHsd * C57BL/6	MGI:4838173

Genotype
MGI:4838173

hm1

• Allelic Composition: Rr156^tm6.1Cog/Rr156^tm6.1Cog
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:165617 )

N • proportions of B and T lymphocytes, monocytes and macrophage are about normal

N • developmental stages of lymphocytes are present in expected numbers

decreased bone marrow cell number ( J:165617 )

• cell counts in bone marrow are somewhat reduced

decreased B cell number ( J:165617 )

• decreased number of B220 cells in the spleen

decreased IgM level ( J:165617 )

• decreased surface expression of IgM on bone marrow B220 cells

immune system

immune system phenotype ( J:165617 )

N • cell numbers in the spleen are normal

N • no effect on class switch recombination

N • antigen activation of B cells is normal

decreased B cell number ( J:165617 )

• decreased number of B220 cells in the spleen

decreased IgM level ( J:165617 )

• decreased surface expression of IgM on bone marrow B220 cells