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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rbfox1tm1.1Dblk
targeted mutation 1.1, Douglas Black
MGI:4838179
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rbfox1tm1.1Dblk/Rbfox1tm1.1Dblk
Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk
Tg(Pcp2-cre)2Mpin/0 		involves: 129 * C57BL/6J MGI:5318257
cn2
 		Rbfox1tm1.1Dblk/Rbfox1+
Tg(Nes-cre)1Kln/0 		involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL MGI:5291909
cn3
 		Rbfox1tm1.1Dblk/Rbfox1tm1.1Dblk
Tg(Nes-cre)1Kln/0 		involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL MGI:5291908
cn4
 		Rbfox1tm1.1Dblk/Rbfox1+
Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk
Tg(Nes-cre)1Kln/0 		involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL MGI:5318256
cn5
 		Rbfox1tm1.1Dblk/Rbfox1tm1.1Dblk
Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk
Tg(Nes-cre)1Kln/0 		involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL MGI:5318255


Genotype
MGI:5318257
cn1
Allelic
Composition		 Rbfox1tm1.1Dblk/Rbfox1tm1.1Dblk
Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk
Tg(Pcp2-cre)2Mpin/0
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbfox1tm1.1Dblk mutation (1 available); any Rbfox1 mutation (33 available)
Rbfox2tm1.1Dblk mutation (1 available); any Rbfox2 mutation (81 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:181631 )
N
• do not display ataxia
impaired coordination ( J:181631 )
• shorter mean latency to fall in the first trial and performance improves only slightly over subsequent trials

nervous system
nervous system phenotype ( J:181631 )
N
• do not display defects in cerebellar development
abnormal neuron physiology ( J:181631 )
• at P70, but not at P20, Purkinje cells show a decrease in firing frequency
• at P70 Purkinje cells show an increase in variability of firing




Genotype
MGI:5291909
cn2
Allelic
Composition		 Rbfox1tm1.1Dblk/Rbfox1+
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbfox1tm1.1Dblk mutation (1 available); any Rbfox1 mutation (33 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
increased susceptibility to pharmacologically induced seizures ( J:176189 )
• increased incidence resulting in death in response to kainic acid treatment

behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:176189 )
• increased incidence resulting in death in response to kainic acid treatment

homeostasis/metabolism




Genotype
MGI:5291908
cn3
Allelic
Composition		 Rbfox1tm1.1Dblk/Rbfox1tm1.1Dblk
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbfox1tm1.1Dblk mutation (1 available); any Rbfox1 mutation (33 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

reproductive system

nervous system
nervous system phenotype ( J:176189 )
N
• mice exhibit normal gross brain morphology
seizures ( J:176189 )
• infrequent spontaneous seizures
increased susceptibility to pharmacologically induced seizures ( J:176189 )
• increased incidence and duration of tonic-clonic seizures resulting in death in response to kainic acid treatment
tonic-clonic seizures ( J:176189 )
• in mice treated with kainic acid
decreased dendritic spine density ( J:176189 )
• very modest decrease in spine density in the dentate gyrus
abnormal excitatory postsynaptic potential ( J:176189 )
• mice require lower stimulus intensities to evoke field excitatory postsynaptic potentials compared with control mice

growth/size/body
decreased body size ( J:176189 )
• slightly

behavior/neurological
seizures ( J:176189 )
• infrequent spontaneous seizures
increased susceptibility to pharmacologically induced seizures ( J:176189 )
• increased incidence and duration of tonic-clonic seizures resulting in death in response to kainic acid treatment
tonic-clonic seizures ( J:176189 )
• in mice treated with kainic acid

homeostasis/metabolism




Genotype
MGI:5318256
cn4
Allelic
Composition		 Rbfox1tm1.1Dblk/Rbfox1+
Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbfox1tm1.1Dblk mutation (1 available); any Rbfox1 mutation (33 available)
Rbfox2tm1.1Dblk mutation (1 available); any Rbfox2 mutation (81 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:181631 )
• euthanasia due to immobility by 3?4 weeks of age

nervous system
abnormal neuron physiology ( J:181631 )
• Purkinje cells show a marked decrease in firing frequency

behavior/neurological
ataxia ( J:181631 )
• develop severe ataxia by 2 weeks of age becoming immobile by 3-4 weeks of age

growth/size/body
decreased body size ( J:181631 )
• very small




Genotype
MGI:5318255
cn5
Allelic
Composition		 Rbfox1tm1.1Dblk/Rbfox1tm1.1Dblk
Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbfox1tm1.1Dblk mutation (1 available); any Rbfox1 mutation (33 available)
Rbfox2tm1.1Dblk mutation (1 available); any Rbfox2 mutation (81 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory