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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt4tm1.2Boer
targeted mutation 1.2, Derek Boerboom
MGI:4838181
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wnt4tm1.2Boer/Wnt4tm1.2Boer involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:4838183
cn2
 		Amhr2tm3(cre)Bhr/Amhr2+
Wnt4tm1.1Boer/Wnt4tm1.2Boer 		involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ MGI:4838185


Genotype
MGI:4838183
hm1
Allelic
Composition		 Wnt4tm1.2Boer/Wnt4tm1.2Boer
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4tm1.2Boer mutation (0 available); any Wnt4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:162337 )
• homozygous mice were found to die within 48 h after birth

renal/urinary system
abnormal kidney development ( J:162337 )
• severe developmental anomalies of the kidneys, reproductive tract, and gonads that were essentially identical to those previously described in Wnt4tm1Amc null mice

reproductive system
abnormal reproductive system development ( J:162337 )
• severe developmental anomalies of the kidneys, reproductive tract, and gonads that were essentially identical to those previously described in Wnt4tm1Amc null mice




Genotype
MGI:4838185
cn2
Allelic
Composition		 Amhr2tm3(cre)Bhr/Amhr2+
Wnt4tm1.1Boer/Wnt4tm1.2Boer
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Wnt4tm1.1Boer mutation (0 available); any Wnt4 mutation (21 available)
Wnt4tm1.2Boer mutation (0 available); any Wnt4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:162337 )
• severe ovarian phenotypes were always accompanied by variable degrees of growth retardation, poor body condition, a disheveled appearance, and frequently premature death

endocrine/exocrine glands
decreased mature ovarian follicle number ( J:162337 )
• ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well
abnormal ovary development ( J:162337 )
• ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well
• fewer healthy antral follicles in 42-d-old mutant female
• small subset of mutant female had very small ovaries that were devoid of antral follicles and corpora lutea at 8?12 wk of age
decreased ovary weight ( J:162337 )
• only 49% the size of those of littermate controls
• all stages of follicular development and corpora lutea could be identified in most adult

reproductive system
decreased mature ovarian follicle number ( J:162337 )
• ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well
abnormal ovary development ( J:162337 )
• ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well
• fewer healthy antral follicles in 42-d-old mutant female
• small subset of mutant female had very small ovaries that were devoid of antral follicles and corpora lutea at 8?12 wk of age
decreased ovary weight ( J:162337 )
• only 49% the size of those of littermate controls
• all stages of follicular development and corpora lutea could be identified in most adult
decreased litter size ( J:162337 )
• average litter size was only 54% that of the control group

growth/size/body
postnatal growth retardation ( J:162337 )
• severe ovarian phenotypes were always accompanied by variable degrees of growth retardation

renal/urinary system
abnormal kidney development ( J:162337 )
• severe developmental anomalies of the kidneys having few glomeruli

integument
disheveled coat ( J:162337 )
• severe ovarian phenotypes were always accompanied by a disheveled appearance




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory