Phenotypes associated with this allele

• Allele Symbol: Wnk1^tm1.1Juha
• Allele Name: targeted mutation 1.1, Juliette Hadchouel
• Allele ID: MGI:4838243
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnk1^tm1.1Juha/Wnk1^tm1.1Juha	involves: 129S2/SvPas * C57BL/6 * C57BL/6N * SJL	MGI:4838248

Genotype
MGI:4838248

hm1

• Allelic Composition: Wnk1^tm1.1Juha/Wnk1^tm1.1Juha
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal urine homeostasis ( J:165537 )

• whether mice are fed a low sodium diet, high sodium diet, or high potassium diet, the 24-hour urine aldosterone level is decreased compared to in wild-type mice

• however, sodium urinary excretion is normal

oliguria ( J:165537 )

• two injection of amiloride leads to a decreased diuresis response compared to in similarly treated wild-type mice

cardiovascular system

increased mean systemic arterial blood pressure ( J:165537 )

increased systemic arterial diastolic blood pressure ( J:165537 )

• slightly

homeostasis/metabolism

abnormal urine homeostasis ( J:165537 )

• whether mice are fed a low sodium diet, high sodium diet, or high potassium diet, the 24-hour urine aldosterone level is decreased compared to in wild-type mice

• however, sodium urinary excretion is normal

decreased physiological sensitivity to xenobiotic ( J:165537 )

• two injection of amiloride leads to a decreased diuresis response compared to in similarly treated wild-type mice