About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr9M7Btlr
mutation 7, Bruce Beutler
MGI:4838258
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr9M7Btlr/Tlr9M7Btlr C57BL/6J-Tlr9M7Btlr MGI:4838259
ht2
 		Tlr9M7Btlr/Tlr9+ C57BL/6J-Tlr9M7Btlr MGI:4838260
cx3
 		Pld4tm1.2Nemz/Pld4tm1.2Nemz
Tlr9M7Btlr/Tlr9M7Btlr 		involves: 129 * C57BL/6J * FVB/N MGI:6452105


Genotype
MGI:4838259
hm1
Allelic
Composition		 Tlr9M7Btlr/Tlr9M7Btlr
Genetic
Background		 C57BL/6J-Tlr9M7Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M7Btlr mutation (1 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:165701 )
• in response to stimulation with oligodeoxynucleotides containing CpG motifs (CpG ODNs), a ligand for Toll-like receptor 9, peritoneal macrophages from mice homozygous for this mutation produce greatly reduced levels (vs. wild-type macrophages) of tumor necrosis factor (TNF-) alpha
• in contrast to their impaired response to a TLR9 ligand, homozygous mutant macrophages produce normal amounts of TNF-alpha upon stimulation with all other Toll-like receptor (TLR) ligands employed in the TLR Signaling Screen (for TLR1/2, TLR3, TLR4, TLR2/6 and TLR7)




Genotype
MGI:4838260
ht2
Allelic
Composition		 Tlr9M7Btlr/Tlr9+
Genetic
Background		 C57BL/6J-Tlr9M7Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M7Btlr mutation (1 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:165701 )
• upon stimulation with oligodeoxynucleotides containing CpG motifs (CpG ODNs), a Toll-like receptor 9 ligand, peritoneal macrophages from mice heterozygous for this mutation produce levels of tumor necrosis factor (TNF-) alpha intermediate between those of wild-type and homozygous mutant mice




Genotype
MGI:6452105
cx3
Allelic
Composition		 Pld4tm1.2Nemz/Pld4tm1.2Nemz
Tlr9M7Btlr/Tlr9M7Btlr
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld4tm1.2Nemz mutation (0 available); any Pld4 mutation (26 available)
Tlr9M7Btlr mutation (1 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:281205 )
N
• no elevation of expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages
• normal B-1 B cell and platelet numbers in peritoneum and normal NK T cell number
• normal marginal zone B cell number
• normal blood monocyte count

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:281205 )
N
• normal circulating interferon-gamma levels

immune system
immune system phenotype ( J:281205 )
N
• normal spleen
• normal plasma CXCL10 levels




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory