Phenotypes associated with this allele

• Allele Symbol: Cd226^tm1Shib
• Allele Name: targeted mutation 1, Akira Shibuya
• Allele ID: MGI:4838287
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd226^tm1Shib/Cd226^tm1Shib	involves: BALB/c	MGI:4838329

Genotype
MGI:4838329

hm1

• Allelic Composition: Cd226^tm1Shib/Cd226^tm1Shib
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:165704 )

• mice transplanted with Meth A tumor cells or treated with 25 ug 3-methylcholantrene (MCA) exhibit increased mortality compared with similarly treated wild-type mice

immune system

abnormal immune system physiology ( J:165704 )

• mice clear fewer RMA-S-CD155 to RMA-S cells than in similarly treated wild-type mice

impaired natural killer cell mediated cytotoxicity ( J:165704 )

• NK fail to exhibit cytolysis towards Yac-1 tumor cells unlike wild-type cells

• NK cells exhibit less cytotoxicity towards RMA-S-CD155 compared with wild-type cells

decreased cytotoxic T cell cytolysis ( J:165704 )

• towards RMA-CD155 and EL-4 cells

neoplasm

increased incidence of induced tumors ( J:165704 )

• all mice transplanted with Meth A cells develop tumors by day 20 compared with 6 of 10 similarly treated wild-type mice

increased incidence of tumors by chemical induction ( J:165704 )

• mice treated with 25 ug 3-methylcholantrene (MCA) exhibit increased fibrosarcoma compared with similarly treated wild-type mice

• mice exhibit 7,12-dimethylbenz[a]anthracene (DMBA)-induced papilloma compared with similarly treated wild-type mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:165704 )

• mice treated with 25 ug 3-methylcholantrene (MCA) exhibit increased fibrosarcoma compared with similarly treated wild-type mice

• mice exhibit 7,12-dimethylbenz[a]anthracene (DMBA)-induced papilloma compared with similarly treated wild-type mice

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:165704 )

• NK fail to exhibit cytolysis towards Yac-1 tumor cells unlike wild-type cells

• NK cells exhibit less cytotoxicity towards RMA-S-CD155 compared with wild-type cells

decreased cytotoxic T cell cytolysis ( J:165704 )

• towards RMA-CD155 and EL-4 cells