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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plcg2m1Btlr
mutation 1, Bruce Beutler
MGI:4838296
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plcg2m1Btlr/Plcg2m1Btlr C57BL/6J-Plcg2m1Btlr MGI:4838297
hm2
 		Plcg2m1Btlr/Plcg2m1Btlr involves: C57BL/6J MGI:5429190


Genotype
MGI:4838297
hm1
Allelic
Composition		 Plcg2m1Btlr/Plcg2m1Btlr
Genetic
Background		 C57BL/6J-Plcg2m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2m1Btlr mutation (1 available); any Plcg2 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:165702 )
• immunization with the T cell independent antigen haptenated Ficoll fails to induce a detectable immunoglobulin M (IgM) response after 5 days in mice homozygous for this mutation
• in contrast to their defective T-independent B lymphocyte response, homozygous mutant mice exhibit a normal immunoglobulin G (IgG) response 14 days after immunization a recombinant suicide vector based on Semlike Forest Virus (rSFV) that encodes T cell dependent model antigens

hematopoietic system
decreased IgM level ( J:165702 )
• immunization with the T cell independent antigen haptenated Ficoll fails to induce a detectable immunoglobulin M (IgM) response after 5 days in mice homozygous for this mutation
• in contrast to their defective T-independent B lymphocyte response, homozygous mutant mice exhibit a normal immunoglobulin G (IgG) response 14 days after immunization a recombinant suicide vector based on Semlike Forest Virus (rSFV) that encodes T cell dependent model antigens




Genotype
MGI:5429190
hm2
Allelic
Composition		 Plcg2m1Btlr/Plcg2m1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2m1Btlr mutation (1 available); any Plcg2 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit a normal response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization

hematopoietic system
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory