Phenotypes associated with this allele

• Allele Symbol: Sst^{tm2.1(cre)Zjh}
• Allele Name: targeted mutation 2.1, Z Josh Huang
• Allele ID: MGI:4838416
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sst^tm2.1(cre)Zjh/Sst^tm2.1(cre)Zjh	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:4838419
cn2	Mecp2^tm1Bird/Y Sst^tm2.1(cre)Zjh/Sst^+	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5749568
cn3	Ptchd1^tm2.1Gfng/Y Sst^tm2.1(cre)Zjh/Sst^+	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J	MGI:5792694
cn4	Eef1a1^tm1Klan/Eef1a1^tm1Klan Sst^tm2.1(cre)Zjh/Sst^+	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J	MGI:6693446
cn5	Col1a1^tm1(tetO-GFP,-RNAi:Eef1a1)Mcg/Col1a1^+ Sst^tm2.1(cre)Zjh/Sst^+	involves: 129S4/SvJae * C57BL/6J	MGI:6693445

Genotype
MGI:4838419

hm1

• Allelic Composition: Sst^{tm2.1(cre)Zjh}/Sst^{tm2.1(cre)Zjh}
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:151755 )

• homozygous mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities

Genotype
MGI:5749568

cn2

• Allelic Composition: Mecp2^tm1Bird/Y; Sst^{tm2.1(cre)Zjh}/Sst⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

mortality/aging

premature death ( J:228740 )

♂ • 50% mortality by 29-35 weeks of age

behavior/neurological

increased stereotypic behavior ( J:228740 )

♂ • mice exhibit repetitive nose-poking behavior in the hole board test

♂ • however, mice do not exhibit motor deficits or alternations in acoustic startle response, partition, or cued memory tests, or differences in anxiety, pre-pulse inhibition, locomotor activity or long-term potentiation

seizures ( J:228740 )

♂ • 50% of mice develop spontaneous epileptic seizures starting at 12 weeks

tonic-clonic seizures ( J:228740 )

♂ • mice show generalized tonic clonic seizures during routine handling

nervous system

seizures ( J:228740 )

♂ • 50% of mice develop spontaneous epileptic seizures starting at 12 weeks

tonic-clonic seizures ( J:228740 )

♂ • mice show generalized tonic clonic seizures during routine handling

Genotype
MGI:5792694

cn3

• Allelic Composition: Ptchd1^tm2.1Gfng/Y; Sst^{tm2.1(cre)Zjh}/Sst⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

behavior/neurological

behavior/neurological phenotype ( J:232709 )

♂N • mice exhibit normal hypertonia and no hyper-aggression

abnormal cognition ( J:232709 )

♂ • attention deficits as in knock-out mice

hyperactivity ( J:232709 )

♂

fragmentation of sleep/wake states ( J:232709 )

♂ • highly fragmented sleep

Genotype
MGI:6693446

cn4

• Allelic Composition: Eef1a1^tm1Klan/Eef1a1^tm1Klan; Sst^{tm2.1(cre)Zjh}/Sst⁺
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

behavior/neurological

impaired cued conditioning behavior ( J:297390 )

• mice infusion with asunaprivir (drug inducer of iPKR) exhibit reduced memory in a cued threat-conditioning paradigm compared with wild-type

Genotype
MGI:6693445

cn5

• Allelic Composition: Col1a1^{tm1(tetO-GFP,-RNAi:Eef1a1)Mcg}/Col1a1⁺; Sst^{tm2.1(cre)Zjh}/Sst⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

behavior/neurological

behavior/neurological phenotype ( J:297390 )

N • mice virally expressing a cre-dependent tet transactivator exhibit normal behavior in an open field and exploration of an elevated plus maze

impaired cued conditioning behavior ( J:297390 )

• mice virally expressing a cre-dependent tet transactivator exhibit reduced long term memory in a cued threat-conditioning paradigm compared with wild-type

• however, supplementation with doxycycline rescues phenotype