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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stk39tm1.2Slin
targeted mutation 1.2, Shih-Hua Lin
MGI:4838422
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stk39tm1.2Slin/Stk39tm1.2Slin involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4838433
ht2
 		Stk39tm1.2Slin/Stk39+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4838436


Genotype
MGI:4838433
hm1
Allelic
Composition		 Stk39tm1.2Slin/Stk39tm1.2Slin
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk39tm1.2Slin mutation (0 available); any Stk39 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

homeostasis/metabolism
increased circulating aldosterone level ( J:165706 )
• secondary hyperaldosteronism
decreased circulating potassium level ( J:165706 )
• decreased plasma potassium ion concentration
decreased urine chloride ion level ( J:165706 )
• decreased fractional excretion of chloride ion after hydrochlorothiazide treatment
increased urine potassium level ( J:165706 )
• increased fractional excretion of potassium
decreased urine sodium level ( J:165706 )
• fractional excretion decreased significantly after hydrochlorothiazide treatment
increased urine magnesium level ( J:165706 )
• increased fractional excretion of magnesium ion

renal/urinary system
decreased urine chloride ion level ( J:165706 )
• decreased fractional excretion of chloride ion after hydrochlorothiazide treatment
increased urine potassium level ( J:165706 )
• increased fractional excretion of potassium
decreased urine sodium level ( J:165706 )
• fractional excretion decreased significantly after hydrochlorothiazide treatment
increased urine magnesium level ( J:165706 )
• increased fractional excretion of magnesium ion

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Gitelman syndrome DOID:0050450 OMIM:263800
 J:165706




Genotype
MGI:4838436
ht2
Allelic
Composition		 Stk39tm1.2Slin/Stk39+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk39tm1.2Slin mutation (0 available); any Stk39 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:165706 )
N
• no electrolyte abnormalities




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory