All Phenotypes Elmo1<tm1.2Ravi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Elmo1^tm1.2Ravi
targeted mutation 1.2, Kodi S Ravichandran
MGI:4838428

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4838438
cn2	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^{tm1c(EUCOMM)Hmgu}/Elmo2^{tm1c(EUCOMM)Hmgu} Myf5^tm3(cre)Sor/Myf5⁺	involves: 129P2/OlaHsd * C57BL/6N	MGI:7545138
cn3	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^{tm1c(EUCOMM)Hmgu}/Elmo2^{tm1c(EUCOMM)Hmgu} Pax3^tm1(cre)Joe/Pax3⁺	involves: 129P2/OlaHsd * C57BL/6N	MGI:7545139
cx4	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^tm1.1Jfco/Elmo2^tm1.1Jfco	involves: 129P2/OlaHsd * C57BL/6	MGI:7545145
cx5	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco	involves: 129P2/OlaHsd * C57BL/6	MGI:7545147
cx6	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^{tm1a(EUCOMM)Hmgu}/Elmo2^{tm1a(EUCOMM)Hmgu}	involves: 129P2/OlaHsd * C57BL/6N	MGI:7545137

Allelic Composition	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1^tm1.2Ravi mutation (0 available); any Elmo1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

multinucleated giant male germ cells ( J:164662 )

abnormal male germ cell apoptosis ( J:164662 )

abnormal testis morphology ( J:164662 )

• mice exhibit an increase in multinucleated giant cell with abundant vacuolar spaces compared to in wild-type mice

abnormal seminiferous tubule morphology ( J:164662 )

• the number of seminiferous tubules containing cell corpses is increased compared to in wild-type mice

abnormal seminiferous tubule epithelium morphology ( J:164662 )

abnormal Sertoli cell morphology ( J:164662 )

• fewer Sertoli cells contain internalization of apoptotic germ cells than in wild-type mice

• however, the number of Sertoli cells is normal

decreased Sertoli cell phagocytosis ( J:164662 )

• Sertoli cells exhibit impaired engulfment of negatively charged 2.1 um carboxylate-modified beads and germ cells compared with wild-type mice

endocrine/exocrine glands

abnormal testis morphology ( J:164662 )

• mice exhibit an increase in multinucleated giant cell with abundant vacuolar spaces compared to in wild-type mice

abnormal seminiferous tubule morphology ( J:164662 )

• the number of seminiferous tubules containing cell corpses is increased compared to in wild-type mice

abnormal seminiferous tubule epithelium morphology ( J:164662 )

abnormal Sertoli cell morphology ( J:164662 )

• fewer Sertoli cells contain internalization of apoptotic germ cells than in wild-type mice

• however, the number of Sertoli cells is normal

cellular

multinucleated giant male germ cells ( J:164662 )

abnormal male germ cell apoptosis ( J:164662 )

Allelic Composition	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^{tm1c(EUCOMM)Hmgu}/Elmo2^{tm1c(EUCOMM)Hmgu} Myf5^tm3(cre)Sor/Myf5⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1^tm1.2Ravi mutation (0 available); any Elmo1 mutation (59 available)
Elmo2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Elmo2 mutation (37 available)
Myf5^tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:331473 )

• no mice are present after weaning

• however, higher than Mendelian ratios at E14.5

muscle

abnormal muscle development ( J:331473 )

• only mononucleated muscle cells at E14.5

• reduced muscle content at E16.5

Allelic Composition	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^{tm1c(EUCOMM)Hmgu}/Elmo2^{tm1c(EUCOMM)Hmgu} Pax3^tm1(cre)Joe/Pax3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1^tm1.2Ravi mutation (0 available); any Elmo1 mutation (59 available)
Elmo2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Elmo2 mutation (37 available)
Pax3^tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:331473 )

• no mice are present after weaning

• however, normal Mendelian ratios at E14.5

muscle

abnormal muscle development ( J:331473 )

• only mononucleated muscle cells at E14.5

• reduced muscle content at E16.5

abnormal diaphragm development ( J:331473 )

• smaller thickness at E16.5 with a failure to attach to the ribs

Allelic Composition	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^tm1.1Jfco/Elmo2^tm1.1Jfco
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1^tm1.2Ravi mutation (0 available); any Elmo1 mutation (59 available)
Elmo2^tm1.1Jfco mutation (0 available); any Elmo2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:331473 )

• fewer than expected mice are present at weaning

muscle

abnormal muscle development ( J:331473 )

• reduced number of nuclei per myofiber indicating less fusion

decreased skeletal muscle fiber size ( J:331473 )

impaired skeletal muscle regeneration ( J:331473 )

• following cardiotoxin-induced injury

Allelic Composition	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1^tm1.2Ravi mutation (0 available); any Elmo1 mutation (59 available)
Elmo2^tm2.1Jfco mutation (0 available); any Elmo2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:331473 )

• no mice are present after weaning

embryonic lethality, incomplete penetrance ( J:331473 )

• fewer than expected mice are present at E14.5

embryo

abnormal embryo development ( J:331473 )

• at E14.5 and E16.5

• however, muscle development is normal

Allelic Composition	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^{tm1a(EUCOMM)Hmgu}/Elmo2^{tm1a(EUCOMM)Hmgu}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1^tm1.2Ravi mutation (0 available); any Elmo1 mutation (59 available)
Elmo2^{tm1a(EUCOMM)Hmgu} mutation (1 available); any Elmo2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:331473 )

• no mice are present at weaning

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