Phenotypes associated with this allele

• Allele Symbol: Caprin1^tm1Mtok
• Allele Name: targeted mutation 1, Makio Tokunaga
• Allele ID: MGI:4838547
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Caprin1^tm1Mtok/Caprin1^tm1Mtok	involves: 129S6/SvEvTac * C57BL/6	MGI:4838573

Genotype
MGI:4838573

hm1

• Allelic Composition: Caprin1^tm1Mtok/Caprin1^tm1Mtok
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:164650 )

nervous system

abnormal dendrite morphology ( J:164650 )

• cultured neurons exhibit shorter, fewer, and less branched dendrites compared with wild-type neurons

abnormal synapse morphology ( J:164650 )

• synaptic protein distribution pattern is abnormal

abnormal neuron physiology ( J:164650 )

• at E17.5, the percentage of motility granules (clusters of sodium potassium ATPase subunit isoform mRNAs) in cerebral cortical neurons is reduced with fewer granules localized to dendrites compared to in wild-type neurons

• dendrites exhibit reduced sodium potassium ATPase activity compared with wild-type neurons

• neuronal networks are poorly developed compared to in wild-type mice

• however, directionality and velocity of granule transport is normal

increased neuron apoptosis ( J:164650 )

• in the cerebrum, thalamus, medulla, and spinal cord

abnormal miniature excitatory postsynaptic currents ( J:164650 )

• half-width of miniature excitatory postsynaptic currents is decreased compared to in wild-type neurons

respiratory system

respiratory failure ( J:164650 )

behavior/neurological

abnormal posture ( J:164650 )

• at E17.5, mice exhibit a bent shape unlike wild-type mice

growth/size/body

decreased fetal size ( J:164650 )

• at E17.5

homeostasis/metabolism

cyanosis ( J:164650 )

cellular

increased neuron apoptosis ( J:164650 )

• in the cerebrum, thalamus, medulla, and spinal cord