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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sav1tm1.1Dupa
targeted mutation 1.1, Duojia Pan
MGI:4838640
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sav1tm1.1Dupa/Sav1tm1.1Dupa
Tg(Vil1-cre)997Gum/0 		involves: 129P2/OlaHsd * C57BL/6J * SJL MGI:4838642
cn2
 		Sav1tm1.1Dupa/Sav1tm1.1Dupa
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Tg(Vil1-cre)997Gum/0 		involves: 129P2/OlaHsd * C57BL/6J * SJL MGI:4838644


Genotype
MGI:4838642
cn1
Allelic
Composition		 Sav1tm1.1Dupa/Sav1tm1.1Dupa
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1tm1.1Dupa mutation (1 available); any Sav1 mutation (20 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal enterocyte proliferation ( J:165471 )
• the colon and small intestine contains increased more and faster proliferating cells compared to in wild-type mice
colon polyps ( J:165471 )
• by 13 months of age, all male mice develop colonic polyps with 'saw-tooth' appearance characteristic of sessile serrated polyps unlike wild-type mice
• 3 months after DSS treatment, mice develop colonic polyps unlike similarly treated wild-type mice and well before homozygous mice not treated with DSS

endocrine/exocrine glands

cellular
abnormal enterocyte proliferation ( J:165471 )
• the colon and small intestine contains increased more and faster proliferating cells compared to in wild-type mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
colonic disease DOID:5353 J:165471




Genotype
MGI:4838644
cn2
Allelic
Composition		 Sav1tm1.1Dupa/Sav1tm1.1Dupa
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1tm1.1Dupa mutation (1 available); any Sav1 mutation (20 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:165471 )
N
• mice exhibit normal cell proliferation in the small intestine and colon
• mice, whether treated with DSS or not, do not develop colonic polyps




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory