Phenotypes associated with this allele

• Allele Symbol: Cxcl12^{tm3.1(HBEGF/EGFP)Tng}
• Allele Name: targeted mutation 3.1, Takashi Nagasawa
• Allele ID: MGI:4838646
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cxcl12^tm3.1(HBEGF/EGFP)Tng/Cxcl12^+	B6.Cg-Cxcl12^tm3.1(HBEGF/EGFP)Tng	MGI:4838648

Genotype
MGI:4838648

ht1

• Allelic Composition: Cxcl12^{tm3.1(HBEGF/EGFP)Tng}/Cxcl12⁺
• Genetic Background: B6.Cg-Cxcl12^{tm3.1(HBEGF/EGFP)Tng}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:164657 )

• mice die 5 days after diphtheria toxin treatment with liver necrosis and hemorrhage

hematopoietic system

abnormal hematopoietic system morphology/development ( J:164657 )

• Diphtheria toxin-treated mice exhibit a reduction in CXCL12-abundant reticular cells compared with untreated mice

decreased common myeloid progenitor cell number ( J:164657 )

• Diphtheria toxin-treated mice exhibit a reduction in megakaryocyte and erythrocyte progenitors (MEP) and granulocyte and macrophage progenitors (GMPs) compared with untreated mice

decreased pro-B cell number ( J:164657 )

• in bone marrow following Diphtheria toxin treatment

decreased bone marrow cell number ( J:164657 )

• after Diphtheria toxin treatment

abnormal common lymphocyte progenitor cell morphology ( J:164657 )

• after Diphtheria toxin treatment, the number of common lymphoid progenitors compared with untreated mice

abnormal proerythroblast morphology ( J:164657 )

• Diphtheria toxin-treated mice lack proerythroblasts compared with untreated mice

abnormal hematopoietic stem cell morphology ( J:164657 )

• hematopoietic stem cells in Diphtheria-treated mice not associated with Cxcl12-abundant reticular cells are smaller than associated cells

decreased hematopoietic stem cell number ( J:164657 )

• Diphtheria toxin-treated mice exhibit decreased long-term repopulating hematopoietic stem cells compared with untreated mice

abnormal hematopoietic system physiology ( J:164657 )

• the repopulating unit in Diphtheria toxin-treated mice is reduced compared to in untreated mice

• Diphtheria toxin-treated mice exhibit more quiescent hematopoietic stem cells than in untreated mice

• Diphtheria toxin-treated mice exhibit early myeloid differentiation of hematopoietic stem cells compared with untreated mice

increased B cell apoptosis ( J:164657 )

• Diphtheria toxin-treated mice exhibit increased pro-B cell apoptosis compared with untreated mice

abnormal bone marrow cell physiology ( J:164657 )

• whole bone marrow cells from Diphtheria-treated mice cultured with piogliazone or BMP2 exhibit reduced differentiation into adipocytes or osteoblasts compared with similarly treated cells from untreated mice

liver/biliary system

liver hemorrhage ( J:164657 )

• after Diphtheria toxin treatment

hepatic necrosis ( J:164657 )

• after Diphtheria toxin treatment

cardiovascular system

liver hemorrhage ( J:164657 )

• after Diphtheria toxin treatment

immune system

increased B cell apoptosis ( J:164657 )

• Diphtheria toxin-treated mice exhibit increased pro-B cell apoptosis compared with untreated mice

decreased pro-B cell number ( J:164657 )

• in bone marrow following Diphtheria toxin treatment

cellular

increased B cell apoptosis ( J:164657 )

• Diphtheria toxin-treated mice exhibit increased pro-B cell apoptosis compared with untreated mice