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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nkaptm1.1Viss
targeted mutation 1.1, Virginia Shapiro
MGI:4839023
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nkaptm1.1Viss/Y
Tg(Lck-cre)1Cwi/0 		involves: 129S1/Sv * 129X1/SvJ MGI:4839039


Genotype
MGI:4839039
cn1
Allelic
Composition		 Nkaptm1.1Viss/Y
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkaptm1.1Viss mutation (0 available); any Nkap mutation (1 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased DN3 thymocyte number ( J:165961 )
• mice exhibit a disproportionate increased (2-fold) in DN3 thymocytes compared to in wild-type mice
arrested T cell differentiation ( J:165961 )
• alpha beta T cell development is incompletely blocked at the DN3 stage unlike in wild-type mice
• however, delta gamma T cell development and pre-TCR signaling are normal

hematopoietic system
increased DN3 thymocyte number ( J:165961 )
• mice exhibit a disproportionate increased (2-fold) in DN3 thymocytes compared to in wild-type mice
arrested T cell differentiation ( J:165961 )
• alpha beta T cell development is incompletely blocked at the DN3 stage unlike in wild-type mice
• however, delta gamma T cell development and pre-TCR signaling are normal

endocrine/exocrine glands
increased DN3 thymocyte number ( J:165961 )
• mice exhibit a disproportionate increased (2-fold) in DN3 thymocytes compared to in wild-type mice




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory