About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rapgef2tm1.1Hous
targeted mutation 1.1, Steven X Hou
MGI:4839105
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rapgef2tm1.1Hous/Rapgef2tm1.1Hous involves: 129S1/Sv MGI:4839182
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous 		involves: 129P2/OlaHsd * 129S1/Sv MGI:4839186
cn3
 		Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(VAV1-cre)1Graf/0 		involves: 129S1/Sv MGI:4839188
cn4
 		Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Cd4-cre)1Cwi/0 		involves: 129S1/Sv * C57BL/6 * CBA MGI:4839185
cn5
 		Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Mx1-cre)1Cgn/0 		involves: 129S1/Sv * C57BL/6 * CBA MGI:4839184
cn6
 		Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S1/Sv * C57BL/6 * CBA MGI:4839181
cn7
 		Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Cdh5-cre)7Mlia/0 		involves: 129S1/Sv * FVB/N MGI:4839187


Genotype
MGI:4839182
hm1
Allelic
Composition		 Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef2tm1.1Hous mutation (1 available); any Rapgef2 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:165879 )
• 15% of tamoxifen-treated mice die at E18.5 to E20.5




Genotype
MGI:4839186
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Rapgef2tm1.1Hous mutation (1 available); any Rapgef2 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:165879 )
N
• mice exhibit normal adult hematopoiesis

immune system
immune system phenotype ( J:165879 )
N
• mice exhibit normal B cell and T cell development




Genotype
MGI:4839188
cn3
Allelic
Composition		 Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(VAV1-cre)1Graf/0
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef2tm1.1Hous mutation (1 available); any Rapgef2 mutation (83 available)
Tg(VAV1-cre)1Graf mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:165879 )
N
• mice exhibit normal adult hematopoiesis

immune system
immune system phenotype ( J:165879 )
N
• mice exhibit normal B cell and T cell development




Genotype
MGI:4839185
cn4
Allelic
Composition		 Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef2tm1.1Hous mutation (1 available); any Rapgef2 mutation (83 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:165879 )
N
• mice exhibit normal adult hematopoiesis

immune system
immune system phenotype ( J:165879 )
N
• mice exhibit normal B cell and T cell development




Genotype
MGI:4839184
cn5
Allelic
Composition		 Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef2tm1.1Hous mutation (1 available); any Rapgef2 mutation (83 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:165879 )
N
• pIpC-treated mice exhibit normal adult hematopoiesis

immune system
immune system phenotype ( J:165879 )
N
• pIpC-treated mice exhibit normal B cell and T cell development




Genotype
MGI:4839181
cn6
Allelic
Composition		 Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef2tm1.1Hous mutation (1 available); any Rapgef2 mutation (83 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:165879 )
• most mice treated with tamoxifen at E11.5 and E13.5 die E17.5 and E18.5 with remaining mice dying at E19.5 to E10.5
• however, mice treated with tamoxifen at E17.5 and E19.5 exhibit the same lethality as in similarly treated Rapgef2tm1.1Hous homozygotes

hematopoietic system
abnormal definitive hematopoiesis ( J:165879 )
• mice treated with tamoxifen at E11.5 and E13.5 exhibit impaired fetal liver hematopoiesis with reduced differentiation of erythroid progenitor cells compared with similarly treated Rapgef2tm1.1Hous homozygotes
decreased erythroid progenitor cell number ( J:165879 )
• at E16.5 in the livers of mice treated with tamoxifen at E11.5 and E13.5

cardiovascular system
abnormal vascular development ( J:165879 )
• at E17.5, mice treated with tamoxifen at E11.5 and E13.5 lack major embryonic blood vessels unlike wild-type mice

growth/size/body
decreased birth body size ( J:165879 )
• in mice treated with tamoxifen at E17.5 and E19.5

liver/biliary system
pale liver ( J:165879 )
• at E16.5 in mice treated with tamoxifen at E11.5 and E13.5

integument
pallor ( J:165879 )
• at E17.5 in mice treated with tamoxifen at E11.5 and E13.5




Genotype
MGI:4839187
cn7
Allelic
Composition		 Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Cdh5-cre)7Mlia/0
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef2tm1.1Hous mutation (1 available); any Rapgef2 mutation (83 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:165879 )
N
• mice exhibit normal adult hematopoiesis

immune system
immune system phenotype ( J:165879 )
N
• mice exhibit normal B cell and T cell development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory