All Phenotypes Mapk11<tm1Jda> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapk11^tm1Jda
targeted mutation 1, Jonathan D Ashwell
MGI:4839280

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk11^tm1Jda/Mapk11^tm1Jda	B6.Cg-Mapk11^tm1Jda	MGI:4839285
cx2	Mapk11^tm1Jda/Mapk11^tm1Jda Mapk14^tm1Jda/Mapk14^tm1Jda	involves: 129 * C57BL/6	MGI:4839286

Allelic Composition	Mapk11^tm1Jda/Mapk11^tm1Jda
Genetic Background	B6.Cg-Mapk11^tm1Jda

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk11^tm1Jda mutation (1 available); any Mapk11 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:165966 )

N	• mice exhibit normal T cell proliferation and polarization

Allelic Composition	Mapk11^tm1Jda/Mapk11^tm1Jda Mapk14^tm1Jda/Mapk14^tm1Jda
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk11^tm1Jda mutation (1 available); any Mapk11 mutation (35 available)
Mapk14^tm1Jda mutation (1 available); any Mapk14 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:165966 )

abnormal T-helper 1 cell differentiation ( J:165966 )

• Th1 polarization is impaired compared to in single homozygote

abnormal T-helper 2 cell differentiation ( J:165966 )

• Th2 polarization is enhanced compared to in single homozygote

abnormal T-helper 17 cell differentiation ( J:165966 )

• Th17 polarization is impaired compared to in single homozygote

decreased interferon-gamma secretion ( J:165966 )

• in response to TCR-stimulation

increased interleukin-10 secretion ( J:165966 )

decreased tumor necrosis factor secretion ( J:165966 )

• in response to TCR-stimulation

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:165966 )

• diminished onset and severity

decreased susceptibility to induced arthritis ( J:165966 )

• diminished onset and severity

skeleton

decreased susceptibility to induced arthritis ( J:165966 )

• diminished onset and severity

hematopoietic system

decreased T cell proliferation ( J:165966 )

abnormal T-helper 1 cell differentiation ( J:165966 )

• Th1 polarization is impaired compared to in single homozygote

abnormal T-helper 2 cell differentiation ( J:165966 )

• Th2 polarization is enhanced compared to in single homozygote

abnormal T-helper 17 cell differentiation ( J:165966 )

• Th17 polarization is impaired compared to in single homozygote

cellular

decreased T cell proliferation ( J:165966 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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