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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk11tm1Jda
targeted mutation 1, Jonathan D Ashwell
MGI:4839280
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk11tm1Jda/Mapk11tm1Jda B6.Cg-Mapk11tm1Jda MGI:4839285
cx2
 		Mapk11tm1Jda/Mapk11tm1Jda
Mapk14tm1Jda/Mapk14tm1Jda 		involves: 129 * C57BL/6 MGI:4839286


Genotype
MGI:4839285
hm1
Allelic
Composition		 Mapk11tm1Jda/Mapk11tm1Jda
Genetic
Background		 B6.Cg-Mapk11tm1Jda
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk11tm1Jda mutation (1 available); any Mapk11 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:165966 )
N
• mice exhibit normal T cell proliferation and polarization




Genotype
MGI:4839286
cx2
Allelic
Composition		 Mapk11tm1Jda/Mapk11tm1Jda
Mapk14tm1Jda/Mapk14tm1Jda
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk11tm1Jda mutation (1 available); any Mapk11 mutation (35 available)
Mapk14tm1Jda mutation (1 available); any Mapk14 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T-helper 1 cell differentiation ( J:165966 )
• Th1 polarization is impaired compared to in single homozygote
abnormal T-helper 2 cell differentiation ( J:165966 )
• Th2 polarization is enhanced compared to in single homozygote
abnormal T-helper 17 cell differentiation ( J:165966 )
• Th17 polarization is impaired compared to in single homozygote
decreased interferon-gamma secretion ( J:165966 )
• in response to TCR-stimulation
decreased tumor necrosis factor secretion ( J:165966 )
• in response to TCR-stimulation
decreased susceptibility to induced arthritis ( J:165966 )
• diminished onset and severity

skeleton
decreased susceptibility to induced arthritis ( J:165966 )
• diminished onset and severity

hematopoietic system
abnormal T-helper 1 cell differentiation ( J:165966 )
• Th1 polarization is impaired compared to in single homozygote
abnormal T-helper 2 cell differentiation ( J:165966 )
• Th2 polarization is enhanced compared to in single homozygote
abnormal T-helper 17 cell differentiation ( J:165966 )
• Th17 polarization is impaired compared to in single homozygote

cellular




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory