mortality/aging
• mice rarely survive beyond weaning
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• fewer than expected mice are present at E13.5
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hematopoietic system
• at E13.5, the number of R4 and R5 cells is increased compared to in wild-type mice
• at E13.5, the number of R2 cells is decreased 4-fold in the bone marrow and 40-fold in the spleen compared to in wild-type mice
• R3 cells contain 2 nuclei unlike in wild-type mice
• more R4 and R5 cells are uncondensed, nucleated, and poorly hemoglobinized compared to in wild-type mice
• the number of R3 cells in G1 is reduced while the number of cells in the G2/M phase is increased compared to in wild-type mice
• at 4 to 6 weeks, the number of Ter119+ erythroid cells is increased 1.3-fold in the bone marrow and 3.7-fold in the spleen compared to in wild-type mice
• erythroid maturation is inhibited compared to in wild-type mice
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• the number of BFU-E and CFU-E are decreased in fetal liver and bone marrow compared to in wild-type mice
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• at 4 to 6 weeks
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• at 4 to 6 weeks
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• at 4 to 6 weeks
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• 10-fold fewer at 4 to 6 weeks
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growth/size/body
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Diamond-Blackfan anemia | DOID:1339 |
OMIM:PS105650 |
J:165876 |