All Phenotypes Pknox1<tm1Fbla> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pknox1^tm1Fbla
targeted mutation 1, Francesco Blasi
MGI:4839363

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pknox1^tm1Fbla/Pknox1^tm1Fbla	B6.Cg-Pknox1^tm1Fbla	MGI:4839417
cx2	Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Pknox1^tm1Fbla/Pknox1^tm1Fbla Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:4839565
cx3	Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Pknox1^tm1Fbla/Pknox1^tm1Fbla	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:4839469
cx4	Pknox1^tm1Fbla/Pknox1^tm1Fbla Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6	MGI:4839564
cx5	Atm^tm1Fwa/Atm^tm1Fwa Pknox1^tm1Fbla/Pknox1⁺	involves: 129S4/SvJae * C57BL/6	MGI:4839470
cx6	Atm^tm1Fwa/Atm^tm1Fwa Pknox1^tm1Fbla/Pknox1^tm1Fbla	involves: 129S4/SvJae * C57BL/6	MGI:4839471

Allelic Composition	Pknox1^tm1Fbla/Pknox1^tm1Fbla
Genetic Background	B6.Cg-Pknox1^tm1Fbla

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pknox1^tm1Fbla mutation (0 available); any Pknox1 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:165811 )

• mice die around E7.5

embryo

embryonic growth retardation ( J:165811 )

decreased embryo size ( J:165811 )

• E7.5

abnormal embryonic tissue morphology ( J:165811 )

• at E7.5 to E7.75, no embryonic derivatives were detected by marker expression unlike in wild-type mice

absent mesoderm ( J:165811 )

• as determined by marker expression

abnormal pluripotent precursor cell morphology ( J:165811 )

• the number of Oct4+ cells is reduced at E6.75 through E8.5 by apoptosis compared to in wild-type mice

failure of primitive streak formation ( J:165811 )

• as determined by marker expression

abnormal extraembryonic tissue morphology ( J:165811 )

• at E7.5 to E7.75, marker expression determined that extra-embryonic compartments are restricted to residual cells of extra-embryonic endoderm and derivatives of visceral ectoderm unlike in wild-type mice

abnormal visceral endoderm morphology ( J:165811 )

• reduced in size

absent anterior visceral endoderm ( J:165811 )

• absent as determined by marker expression

growth/size/body

embryonic growth retardation ( J:165811 )

decreased embryo size ( J:165811 )

• E7.5

Allelic Composition	Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Pknox1^tm1Fbla/Pknox1^tm1Fbla Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1.1Brn mutation (1 available); any Cdkn2a mutation (67 available)
Pknox1^tm1Fbla mutation (0 available); any Pknox1 mutation (90 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (239 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:165811 )

• no mice are recovered (no time of death given)

Allelic Composition	Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Pknox1^tm1Fbla/Pknox1^tm1Fbla
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal pluripotent precursor cell morphology ( J:165811 )

• mice exhibit the same reduced Oct4 expression domain as in Pknox1^tm1Fbla homozygotes

Allelic Composition	Pknox1^tm1Fbla/Pknox1^tm1Fbla Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pknox1^tm1Fbla mutation (0 available); any Pknox1 mutation (90 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (239 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:165811 )

• mice are almost reabsorbed between E9.5 and E10.5

embryo

abnormal embryo development ( J:165811 )

• anterior visceral endoderm and primitive streak formation are partially rescued compared to in Pknox1^tm1Fbla homozygotes

embryonic growth retardation ( J:165811 )

• at E8.5

abnormal embryonic epiblast morphology ( J:165811 )

abnormal pluripotent precursor cell morphology ( J:165811 )

• the Oct4 expression domain is expanded with a decrease in apoptosis compared to in Pknox1^tm1Fbla homozygotes

abnormal extraembryonic endoderm formation ( J:165811 )

• the extra-embryonic ectoderm is better organized than in Pknox1^tm1Fbla homozygotes

growth/size/body

embryonic growth retardation ( J:165811 )

• at E8.5

Allelic Composition	Atm^tm1Fwa/Atm^tm1Fwa Pknox1^tm1Fbla/Pknox1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Fwa mutation (2 available); any Atm mutation (170 available)
Pknox1^tm1Fbla mutation (0 available); any Pknox1 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryonic growth retardation ( J:165811 )

• in 2 of 4 mice

growth/size/body

embryonic growth retardation ( J:165811 )

• in 2 of 4 mice

Allelic Composition	Atm^tm1Fwa/Atm^tm1Fwa Pknox1^tm1Fbla/Pknox1^tm1Fbla
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:165811 )

• only one mouse is recovered at E7.5

embryo

embryonic growth retardation ( J:165811 )

• in the single mouse generated

abnormal pluripotent precursor cell morphology ( J:165811 )

• at E7.5, Oct4+ cells are almost undetectable in the single mouse generated

growth/size/body

embryonic growth retardation ( J:165811 )

• in the single mouse generated

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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