All Phenotypes Med12<tm1Hsch> MGI Mouse

embryonic lethality, complete penetrance ( J:166040 )

• ES cells fail to generate mice

embryonic lethality during organogenesis, complete penetrance ( J:166040 )

• tetraploid complementation rescue results in aberrant embryos at E9.5

• no living embryos at E10.5

abnormal neural crest cell migration ( J:166040 )

• neural crest cells fail to migrate

abnormal pharyngeal arch morphology ( J:166040 )

abnormal first pharyngeal arch morphology ( J:166040 )

• reduced or absent in embryos resulting from tetraploid complementation rescue

absent second pharyngeal arch ( J:166040 )

absent third pharyngeal arch ( J:166040 )

caudal body truncation ( J:166040 )

• severe posterior axis truncation

• caudal end mesenchyme absent

abnormal head mesenchyme morphology ( J:166040 )

• reduced head mesenchyme

abnormal neural tube morphology ( J:166040 )

open neural tube ( J:166040 )

• open neural tube at E9.5 after tetraploid complementation rescue

• some neural tube closure at the level of the heart occasionally

• completely flat neural plate in some cases

kinked neural tube ( J:166040 )

• frequently

abnormal somite development ( J:166040 )

abnormal dorsal-ventral polarity of the somites ( J:166040 )

• somite abnormalities increase in a caudal direction

abnormal somite shape ( J:166040 )

• irregular and undifferentiated

decreased somite size ( J:166040 )

• smaller somites

abnormal heart development ( J:166040 )

• enlarged in embryos resulting from tetraploid complementation rescue

failure of heart looping ( J:166040 )

• heart fails to loop