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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Med12tm1.1Hsch
targeted mutation 1.1, Heinrich Schrewe
MGI:4839485
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Med12tm1.1Hsch/Med12tm1.1Hsch involves: 129S6/SvEvTac * C57BL/6NCrl MGI:4839515
cn2
 		Med12tm1.1Hsch/Med12+
Tg(CMV-cre)1Cgn/0 		involves: 129S6/SvEvTac * C57BL/6 MGI:4839553
ot3
 		Med12tm1.1Hsch/Y involves: 129S6/SvEvTac * C57BL/6NCrl MGI:4839514


Genotype
MGI:4839515
hm1
Allelic
Composition		 Med12tm1.1Hsch/Med12tm1.1Hsch
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med12tm1.1Hsch mutation (0 available); any Med12 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:166040 )
• mice are fertile with no abnormal phenotype




Genotype
MGI:4839553
cn2
Allelic
Composition		 Med12tm1.1Hsch/Med12+
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med12tm1.1Hsch mutation (0 available); any Med12 mutation (6 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:166045 )
• only one female in 16 live births
embryonic lethality during organogenesis, incomplete penetrance ( J:166045 )
• fewer female embryos from a cross of hemizygous males and homozygous cre expressing females at E13.5

embryo
abnormal neural tube morphology ( J:166045 )
• neural tube defects of variable severity at E11.5 in females
craniorachischisis ( J:166045 )
• in 30% of E12.5 mice

nervous system
abnormal neural tube morphology ( J:166045 )
• neural tube defects of variable severity at E11.5 in females
craniorachischisis ( J:166045 )
• in 30% of E12.5 mice
exencephaly ( J:166045 )
• exencephaly and spina bifida in 63% of mice over E12.5

skeleton
abnormal neurocranium morphology ( J:166045 )
• some calvarial bones missing

limbs/digits/tail
curly tail ( J:166045 )
• in 18 of 22 mice

craniofacial
abnormal neurocranium morphology ( J:166045 )
• some calvarial bones missing




Genotype
MGI:4839514
ot3
Allelic
Composition		 Med12tm1.1Hsch/Y
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med12tm1.1Hsch mutation (0 available); any Med12 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:166040 )
• mice are fertile with no abnormal phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory