Phenotypes associated with this allele

• Allele Symbol: Epo^tm1Knni
• Allele Name: targeted mutation 1, Knut Niss
• Allele ID: MGI:4839526
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Epo^tm1Knni/Epo^tm1Knni Gt(ROSA)26Sor^tm9(cre/ESR1)Arte/Gt(ROSA)26Sor^+	involves: 129S/Sv * C57BL/6	MGI:4839528
cn2	Epo^tm1Knni/Epo^tm1Knni Tg(EIIa-cre)C5379Lmgd/0	involves: C57BL/6 * FVB/N	MGI:4839527

Genotype
MGI:4839528

cn1

• Allelic Composition: Epo^tm1Knni/Epo^tm1Knni; Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal erythropoiesis ( J:165479 )

• a decrease in the CD71- Ter119+ population, an intermediate erythroid progenitor stage in the bone marrow

decreased erythrocyte cell number ( J:165479 )

• 50 days after tamoxifen induction with a subcutaneous pellet

decreased hematocrit ( J:165479 )

• 50 days after tamoxifen induction with a subcutaneous pellet

decreased hemoglobin content ( J:165479 )

• 50 days after tamoxifen induction with a subcutaneous pellet

Genotype
MGI:4839527

cn2

• Allelic Composition: Epo^tm1Knni/Epo^tm1Knni; Tg(EIIa-cre)C5379Lmgd/0
• Genetic Background: involves: C57BL/6 * FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:165479 )

• embryos died at 12.5 days post-coitum with severe defects in erythropoiesis

hematopoietic system

decreased erythrocyte cell number ( J:165479 )

• significant reduction in RBCs in the liver