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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm7(SMO*/YFP)Amc
targeted mutation 7, Andrew P McMahon
MGI:4839792
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm7(SMO*/YFP)Amc
Tg(CAG-cre/Esr1*)5Amc/0 		chimera involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster MGI:4839957
cn2
 		Gt(ROSA)26Sortm7(SMO*/YFP)Amc/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster MGI:4839958


Genotype
MGI:4839957
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm7(SMO*/YFP)Amc
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 chimera involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Gt(ROSA)26Sortm7(SMO*/YFP)Amc mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain development ( J:165962 )
• dorsal CNS hyperproliferation at E13.5 after being exposed at E8.5 to tamoxifen

limbs/digits/tail
polydactyly ( J:165962 )
• observed at E13.5 after being exposed at E8.5 to tamoxifen




Genotype
MGI:4839958
cn2
Allelic
Composition		 Gt(ROSA)26Sortm7(SMO*/YFP)Amc/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm7(SMO*/YFP)Amc mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain development ( J:165962 )
• display severe dorsal CNS overgrowth

craniofacial
abnormal frontonasal prominence morphology ( J:165962 )
• display dysmorphology of the frontonasal processes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory