Phenotypes associated with this allele

• Allele Symbol: Gldn^tm1Pele
• Allele Name: targeted mutation 1, Elior Peles
• Allele ID: MGI:4840020
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gldn^tm1Pele/Gldn^tm1Pele	involves: ICR	MGI:4840022
cx2	Cntnap1^tm1Pele/Cntnap1^tm1Pele Gldn^tm1Pele/Gldn^tm1Pele	involves: ICR	MGI:4840026

Genotype
MGI:4840022

hm1

• Allelic Composition: Gldn^tm1Pele/Gldn^tm1Pele
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:166099 )

N • mice do not exhibit neurological abnormalities and have normal nerve conduction

abnormal axon morphology ( J:166099 )

• mice exhibit disorganization and impaired attachment of Schwann cell microvilli to the nodal axolemma compared with wild-type mice

• sodium ion channels are absent from heminodes but accumulate in mature nodes unlike in wild-type mice

• heminodes fail to form unlike in wild-type mice

• however, nodes form normally

behavior/neurological

behavior/neurological phenotype ( J:166099 )

N • mice do not exhibit neurological abnormalities

Genotype
MGI:4840026

cx2

• Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele; Gldn^tm1Pele/Gldn^tm1Pele
• Genetic Background: involves: ICR

mortality/aging

postnatal lethality, complete penetrance ( J:166099 )

• at P15

nervous system

abnormal axon morphology ( J:166099 )

• nodes and heminodes fail to form unlike in wild-type mice

• nodal length is increased compared to in wild-type mice

decreased nerve conduction velocity ( J:166099 )

• at P14

behavior/neurological

ataxia ( J:166099 )

• strong congenital at P5