All Phenotypes Meg3<tm1Itl> MGI Mouse

mortality/aging

perinatal lethality, complete penetrance ( J:166176 )

• mice inheriting the mutation maternally die perinatally with no milk in their stomachs and non-inflated lungs

cellular

• in mice inheriting the mutation maternally, maternally expressed genes are silenced and paternally expressed genes are activated and both the maternal and paternal alleles of the nearby intergenic differentially methylated region and the differentially methylated region associated with the gene are methylated in embryos

paternal imprinting ( J:166176 )

muscle

abnormal muscle development ( J:166176 )

• in embryos inheriting the mutation maternally muscle maturation beyond the myotube stage is delayed

abnormal skeletal muscle fiber morphology ( J:166176 )

• in mice inheriting the mutation maternally muscles consist mainly of myofibers with centrally localized nuclei or areas of central clearing characteristics of immature muscle fibers

respiratory system

respiratory failure ( J:166176 )

• lungs of neonates inheriting the mutation maternally fail to inflate

growth/size/body

decreased fetal weight ( J:166176 )

• mice inheriting the mutation paternally weigh about 13.3% less than their wild-type littermates at E18.5

embryo

decreased placenta weight ( J:166176 )

• in mice inheriting the mutation paternally

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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