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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lmnatm7Lgf
targeted mutation 7, Loren G Fong
MGI:4840061
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lmnatm7Lgf/Lmnatm7Lgf involves: 129P2/OlaHsd * C57BL/6 MGI:4840104
ht2
 		Lmnatm7Lgf/Lmna+ involves: 129P2/OlaHsd * C57BL/6 MGI:4840105
ht3
 		Lmnatm1Stw/Lmnatm7Lgf involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:4840108
ht4
 		Lmnatm2Lgf/Lmnatm7Lgf involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4840106
cx5
 		Lmnatm7Lgf/Lmna+
Zmpste24tm1Sgy/Zmpste24tm1Sgy 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4840110


Genotype
MGI:4840104
hm1
Allelic
Composition		 Lmnatm7Lgf/Lmnatm7Lgf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm7Lgf mutation (0 available); any Lmna mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Misshapen cell nuclei in embryonic Lmnatm7Lgf/Lmnatm7Lgf fibroblasts

mortality/aging
mortality/aging ( J:165928 )
N
• mice exhibit normal survival

cellular
abnormal cell nucleus morphology ( J:165928 )
• fibroblasts exhibit a higher frequency of nuclei blebs compared with cells from wild-type mice and Lmnatm6Lgf homozygotes
• however, nuclear stiffness in fibroblalsts is normal

reproductive system
reproductive system phenotype ( J:165928 )
N
• mice are fertile




Genotype
MGI:4840105
ht2
Allelic
Composition		 Lmnatm7Lgf/Lmna+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm7Lgf mutation (0 available); any Lmna mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular




Genotype
MGI:4840108
ht3
Allelic
Composition		 Lmnatm1Stw/Lmnatm7Lgf
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1Stw mutation (3 available); any Lmna mutation (84 available)
Lmnatm7Lgf mutation (0 available); any Lmna mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular




Genotype
MGI:4840106
ht4
Allelic
Composition		 Lmnatm2Lgf/Lmnatm7Lgf
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm2Lgf mutation (0 available); any Lmna mutation (84 available)
Lmnatm7Lgf mutation (0 available); any Lmna mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular




Genotype
MGI:4840110
cx5
Allelic
Composition		 Lmnatm7Lgf/Lmna+
Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm7Lgf mutation (0 available); any Lmna mutation (84 available)
Zmpste24tm1Sgy mutation (2 available); any Zmpste24 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:165928 )
N
• mice exhibit normal survival

skeleton
decreased susceptibility to bone fracture ( J:165928 )
• compared to in Zmpste24tm1Sgy homozygotes

growth/size/body
growth/size/body region phenotype ( J:165928 )
N
• body weight is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory