About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lmnatm7Lgf
targeted mutation 7, Loren G Fong
MGI:4840061
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lmnatm7Lgf/Lmnatm7Lgf involves: 129P2/OlaHsd * C57BL/6 MGI:4840104
ht2
Lmnatm7Lgf/Lmna+ involves: 129P2/OlaHsd * C57BL/6 MGI:4840105
ht3
Lmnatm1Stw/Lmnatm7Lgf involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:4840108
ht4
Lmnatm2Lgf/Lmnatm7Lgf involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4840106
cx5
Lmnatm7Lgf/Lmna+
Zmpste24tm1Sgy/Zmpste24tm1Sgy
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4840110


Genotype
MGI:4840104
hm1
Allelic
Composition
Lmnatm7Lgf/Lmnatm7Lgf
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm7Lgf mutation (0 available); any Lmna mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Misshapen cell nuclei in embryonic Lmnatm7Lgf/Lmnatm7Lgf fibroblasts

mortality/aging
N
• mice exhibit normal survival

cellular
• fibroblasts exhibit a higher frequency of nuclei blebs compared with cells from wild-type mice and Lmnatm6Lgf homozygotes
• however, nuclear stiffness in fibroblalsts is normal

reproductive system
N
• mice are fertile




Genotype
MGI:4840105
ht2
Allelic
Composition
Lmnatm7Lgf/Lmna+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm7Lgf mutation (0 available); any Lmna mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular




Genotype
MGI:4840108
ht3
Allelic
Composition
Lmnatm1Stw/Lmnatm7Lgf
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1Stw mutation (3 available); any Lmna mutation (84 available)
Lmnatm7Lgf mutation (0 available); any Lmna mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular




Genotype
MGI:4840106
ht4
Allelic
Composition
Lmnatm2Lgf/Lmnatm7Lgf
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm2Lgf mutation (0 available); any Lmna mutation (84 available)
Lmnatm7Lgf mutation (0 available); any Lmna mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular




Genotype
MGI:4840110
cx5
Allelic
Composition
Lmnatm7Lgf/Lmna+
Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm7Lgf mutation (0 available); any Lmna mutation (84 available)
Zmpste24tm1Sgy mutation (2 available); any Zmpste24 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal survival

skeleton
• compared to in Zmpste24tm1Sgy homozygotes

growth/size/body
N
• body weight is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory