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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adgra2tm1Cjku
targeted mutation 1, Calvin J Kuo
MGI:4840264
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adgra2tm1Cjku/Adgra2tm1Cjku involves: 129 MGI:4840267
cn2
 		Adgra2tm1Cjku/Adgra2tm2Cjku
Tg(Tek-cre)12Flv/0 		involves: 129/Sv * C3H * C57BL/6 MGI:4840270
cn3
 		Adgra2tm1Cjku/Adgra2tm2Cjku
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 		involves: 129/Sv * C57BL/6 * CBA MGI:4840269


Genotype
MGI:4840267
hm1
Allelic
Composition		 Adgra2tm1Cjku/Adgra2tm1Cjku
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm1Cjku mutation (0 available); any Adgra2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:166127 )
• from E15.5 onwards; no embryos are recovered at E17.5

cardiovascular system
abnormal blood vessel morphology ( J:166127 )
• numerous packed endothelial cells with scant cytoplasm enveloped by pericytes are seen in CNS vascular malformations
abnormal angiogenesis ( J:166127 )
• CNS specific vascular patterning defects
abnormal vascular branching morphogenesis ( J:166127 )
• decrease in angiogenic sprouting into the forebrain telencephalon and thickening of the underlying perineural vascular plexus resulting in a nearly avascular telencephalon
• by E14.5 defects in sprouting result in basally localized glomeruloid malformations and a distally avascular telencephalon
• filopodial extensions are reduced or absent in endothelial cells in the glomeruloid malformations and when present extend laterally rather than towards the ventricles
• however, sprouting is not affected in the embryonic diencephalon, mid- and hindbrain, or in nonneural tissues
abnormal perineural vascular plexus morphology ( J:166127 )
• decrease in angiogenic sprouting into the forebrain telencephalon and thickening of the underlying perineural vascular plexus resulting in a nearly avascular telencephalon
internal hemorrhage ( J:166127 )
• beginning at E11.5 embryos display progressive central nervous system (CNS) hemorrhage originating in forebrain telencephalon and ventral neural tube
• by E14.5 hemorrhagic glomeruloid malformations are seen in the telencephalon, ventral neural tube and forebrain ganglionic eminences

nervous system
abnormal neural tube morphology ( J:166127 )
• by E14.5 hemorrhagic glomeruloid malformations are seen in the ventral neural tube
abnormal telencephalon morphology ( J:166127 )
• decrease in angiogenic sprouting into the forebrain telencephalon and thickening of the underlying perineural vascular plexus resulting in a nearly avascular telencephalon
• by E14.5 defects in sprouting result in basally localized glomeruloid malformations and a distally avascular telencephalon
abnormal embryonic/fetal subventricular zone morphology ( J:166127 )
• by E14.5 hemorrhagic glomeruloid malformations are seen in the forebrain ganglionic eminences
abnormal nervous system physiology ( J:166127 )
• beginning at E11.5 embryos display progressive central nervous system (CNS) hemorrhage originating in forebrain telencephalon and ventral neural tube

embryo
abnormal neural tube morphology ( J:166127 )
• by E14.5 hemorrhagic glomeruloid malformations are seen in the ventral neural tube




Genotype
MGI:4840270
cn2
Allelic
Composition		 Adgra2tm1Cjku/Adgra2tm2Cjku
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129/Sv * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm1Cjku mutation (0 available); any Adgra2 mutation (43 available)
Adgra2tm2Cjku mutation (0 available); any Adgra2 mutation (43 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel morphology ( J:166127 )
• basally localized glomeruloid malformations in hemorrhagic areas of the CNS
internal hemorrhage ( J:166127 )
• stated to be identical to the phenotype seen in mice homozygous for Gpr124tm1Cjku
• forebrain hemorrhage




Genotype
MGI:4840269
cn3
Allelic
Composition		 Adgra2tm1Cjku/Adgra2tm2Cjku
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm1Cjku mutation (0 available); any Adgra2 mutation (43 available)
Adgra2tm2Cjku mutation (0 available); any Adgra2 mutation (43 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel morphology ( J:166127 )
• basally localized glomeruloid malformations in hemorrhagic areas of the CNS
abnormal vascular branching morphogenesis ( J:166127 )
• central nervous system (CNS) angiogenic arrest
internal hemorrhage ( J:166127 )
• stated to fully recapitulate the phenotype seen in mice homozygous for Gpr124tm1Cjku
• forebrain hemorrhage




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory