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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adgra2tm2Cjku
targeted mutation 2, Calvin J Kuo
MGI:4840265
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adgra2tm1Cjku/Adgra2tm2Cjku
Tg(Tek-cre)12Flv/0 		involves: 129/Sv * C3H * C57BL/6 MGI:4840270
cn2
 		Adgra2tm1Cjku/Adgra2tm2Cjku
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 		involves: 129/Sv * C57BL/6 * CBA MGI:4840269


Genotype
MGI:4840270
cn1
Allelic
Composition		 Adgra2tm1Cjku/Adgra2tm2Cjku
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129/Sv * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm1Cjku mutation (0 available); any Adgra2 mutation (43 available)
Adgra2tm2Cjku mutation (0 available); any Adgra2 mutation (43 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel morphology ( J:166127 )
• basally localized glomeruloid malformations in hemorrhagic areas of the CNS
internal hemorrhage ( J:166127 )
• stated to be identical to the phenotype seen in mice homozygous for Gpr124tm1Cjku
• forebrain hemorrhage




Genotype
MGI:4840269
cn2
Allelic
Composition		 Adgra2tm1Cjku/Adgra2tm2Cjku
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm1Cjku mutation (0 available); any Adgra2 mutation (43 available)
Adgra2tm2Cjku mutation (0 available); any Adgra2 mutation (43 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel morphology ( J:166127 )
• basally localized glomeruloid malformations in hemorrhagic areas of the CNS
abnormal vascular branching morphogenesis ( J:166127 )
• central nervous system (CNS) angiogenic arrest
internal hemorrhage ( J:166127 )
• stated to fully recapitulate the phenotype seen in mice homozygous for Gpr124tm1Cjku
• forebrain hemorrhage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory