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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcl1tm1Dmta
targeted mutation 1, David M Tarlinton
MGI:4840274
Summary 4 genotypes


Genotype
MGI:4840320
cn1
Allelic
Composition		 Mcl1tm1Dmta/Mcl1tm1Dmta
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Mcl1tm1Dmta mutation (0 available); any Mcl1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:166069 )
• when bone marrow cells are used to reconstitute lethally irradiated mice, NP-KLH and tamoxifen treated chimeras exhibit a reduction in IgM+ plasma blasts cells compared to when wild-type bone marrow are used
absent germinal center B cells ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH
absent memory B cells ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH
decreased naive B cell number ( J:166069 )
• greater than 5-fold following tamoxifen-treatment

hematopoietic system
abnormal B cell differentiation ( J:166069 )
• when bone marrow cells are used to reconstitute lethally irradiated mice, NP-KLH and tamoxifen treated chimeras exhibit a reduction in IgM+ plasma blasts cells compared to when wild-type bone marrow are used
absent germinal center B cells ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH
absent memory B cells ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH
decreased naive B cell number ( J:166069 )
• greater than 5-fold following tamoxifen-treatment




Genotype
MGI:4840321
cn2
Allelic
Composition		 Mcl1tm1Dmta/Mcl1+
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Mcl1tm1Dmta mutation (0 available); any Mcl1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased germinal center B cell number ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH
decreased memory B cell number ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH

hematopoietic system
decreased germinal center B cell number ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH
decreased memory B cell number ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH




Genotype
MGI:4840315
cn3
Allelic
Composition		 Mcl1tm1Dmta/Mcl1tm1Dmta
Tg(Aicda-cre)9Mbu/0
Genetic
Background		 B6.Cg-Mcl1tm1Dmta Tg(Aicda-cre)9Mbu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Dmta mutation (0 available); any Mcl1 mutation (35 available)
Tg(Aicda-cre)9Mbu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:166069 )
N
• affinity maturation among NP-reactive B cells is normal
absent germinal center B cells ( J:166069 )
• following immunization with NP-KLH
absent memory B cells ( J:166069 )
• following immunization with NP-KLH
decreased IgG1 level ( J:166069 )
• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the serum, spleen and bone marrow compared to in similarly treated wild-type mice

hematopoietic system
absent germinal center B cells ( J:166069 )
• following immunization with NP-KLH
absent memory B cells ( J:166069 )
• following immunization with NP-KLH
decreased IgG1 level ( J:166069 )
• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the serum, spleen and bone marrow compared to in similarly treated wild-type mice




Genotype
MGI:4840316
cn4
Allelic
Composition		 Mcl1tm1Dmta/Mcl1+
Tg(Aicda-cre)9Mbu/0
Genetic
Background		 B6.Cg-Mcl1tm1Dmta Tg(Aicda-cre)9Mbu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Dmta mutation (0 available); any Mcl1 mutation (35 available)
Tg(Aicda-cre)9Mbu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased germinal center B cell number ( J:166069 )
• following immunization with NP-KLH
decreased memory B cell number ( J:166069 )
• following immunization with NP-KLH

hematopoietic system
decreased germinal center B cell number ( J:166069 )
• following immunization with NP-KLH
decreased memory B cell number ( J:166069 )
• following immunization with NP-KLH




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory