Phenotypes associated with this allele

• Allele Symbol: Ntrk2^tm2.1Mini
• Allele Name: targeted mutation 2.1, Liliana Minichiello
• Allele ID: MGI:4840323
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk2^tm2.1Mini/Ntrk2^tm2.1Mini	involves: 129P2/OlaHsd	MGI:4840348

Genotype
MGI:4840348

hm1

• Allelic Composition: Ntrk2^tm2.1Mini/Ntrk2^tm2.1Mini
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:132562 )

• mice die between 2 and 4 weeks

nervous system

abnormal neuron differentiation ( J:132562 )

• expression of parvalbumin in the entorhinal cortex and the hippocampus is reduced compared to in wild-type mice

• in the most superficial layers of the neocortex dendrites are fasiculated and poorly stained while in the deepest layers (V-VI) staining is reduced compared to in wild-type mice

abnormal axon fasciculation ( J:132562 )

• in the most superficial layers of the neocortex dendrites are fasiculated and poorly stained while in the deepest layers (V-VI) staining is reduced compared to in wild-type mice

abnormal neuronal migration ( J:132562 )

• delayed at E18.5

abnormal cerebral cortex morphology ( J:132562 )

• layer II/III is slightly compressed with tightly packed neurons compared to in wild-type mice

astrocytosis ( J:132562 )

growth/size/body

postnatal growth retardation ( J:132562 )

• after P7

hearing/vestibular/ear

abnormal vestibular labyrinth morphology ( J:132562 )

cellular

abnormal neuron differentiation ( J:132562 )

• expression of parvalbumin in the entorhinal cortex and the hippocampus is reduced compared to in wild-type mice

• in the most superficial layers of the neocortex dendrites are fasiculated and poorly stained while in the deepest layers (V-VI) staining is reduced compared to in wild-type mice

abnormal axon fasciculation ( J:132562 )

• in the most superficial layers of the neocortex dendrites are fasiculated and poorly stained while in the deepest layers (V-VI) staining is reduced compared to in wild-type mice

abnormal neuronal migration ( J:132562 )

• delayed at E18.5