Phenotypes associated with this allele

• Allele Symbol: Tbata^tm1Faf
• Allele Name: targeted mutation 1, Francis A Flomerfelt
• Allele ID: MGI:4840354
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbata^tm1Faf/Tbata^tm1Faf	involves: 129P2/OlaHsd * C57BL/6	MGI:4840361
cx2	Rag2^tm1Fwa/Rag2^tm1Fwa Tbata^tm1Faf/Tbata^tm1Faf	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:4840364

Genotype
MGI:4840361

hm1

• Allelic Composition: Tbata^tm1Faf/Tbata^tm1Faf
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:166065 )

N • T cell development and function are normal

abnormal thymus epithelium morphology ( J:166065 )

• at 6 to 9 months, thymic epithelial cell numbers are increased compared to in wild-type mice

enlarged thymus ( J:166065 )

• in aged mice

thymus hyperplasia ( J:166065 )

• at 5 to 9 months, twice as many thymocytes are present compared to in wild-type mice

• at 1 year of age, thymocyte numbers are 4-fold greater while stromal cell numbers are 2-fold greater than in wild-type mice

increased thymocyte number ( J:166065 )

• 2-fold at 5 to 9 months of age

• 4-fold at 1 year of age

increased double-negative T cell number ( J:166065 )

• 4- to 5-fold

nervous system

abnormal cerebellum external granule cell layer morphology ( J:166065 )

• mice exhibit abnormal nests of retained external germinal layer in the cerebellum unlike in wild-type mice that persists in aged mice

reproductive system

reproductive system phenotype ( J:166065 )

N • mice exhibit normal testes

hematopoietic system

abnormal thymus epithelium morphology ( J:166065 )

• at 6 to 9 months, thymic epithelial cell numbers are increased compared to in wild-type mice

enlarged thymus ( J:166065 )

• in aged mice

thymus hyperplasia ( J:166065 )

• at 5 to 9 months, twice as many thymocytes are present compared to in wild-type mice

• at 1 year of age, thymocyte numbers are 4-fold greater while stromal cell numbers are 2-fold greater than in wild-type mice

increased thymocyte number ( J:166065 )

• 2-fold at 5 to 9 months of age

• 4-fold at 1 year of age

increased double-negative T cell number ( J:166065 )

• 4- to 5-fold

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:166065 )

• at 6 to 9 months, thymic epithelial cell numbers are increased compared to in wild-type mice

enlarged thymus ( J:166065 )

• in aged mice

thymus hyperplasia ( J:166065 )

• at 5 to 9 months, twice as many thymocytes are present compared to in wild-type mice

• at 1 year of age, thymocyte numbers are 4-fold greater while stromal cell numbers are 2-fold greater than in wild-type mice

increased thymocyte number ( J:166065 )

• 2-fold at 5 to 9 months of age

• 4-fold at 1 year of age

Genotype
MGI:4840364

cx2

• Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa; Tbata^tm1Faf/Tbata^tm1Faf
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

immune system

increased thymocyte number ( J:166065 )

• at 8 weeks

• 3- to 4-fold at 3 months

abnormal T cell differentiation ( J:166065 )

• thymocyte development arrests at the DN3 stage unlike in wild-type mice

hematopoietic system

increased thymocyte number ( J:166065 )

• at 8 weeks

• 3- to 4-fold at 3 months

abnormal T cell differentiation ( J:166065 )

• thymocyte development arrests at the DN3 stage unlike in wild-type mice

abnormal bone marrow cell physiology ( J:166065 )

• in reconstitution experiments, thymocyte numbers are increased and thymic reconstitution dependent on stromal cells is enhanced compared to when wild-type bone marrow is used

endocrine/exocrine glands

increased thymocyte number ( J:166065 )

• at 8 weeks

• 3- to 4-fold at 3 months