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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bco2tm1Dnp
targeted mutation 1, Adrian Wyss
MGI:4840382
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bco2tm1Dnp/Bco2tm1Dnp involves: 129S6/SvEvTac * C57BL/6 MGI:4840384
ht2
Bco2tm1Dnp/Bco2+ involves: 129S6/SvEvTac * C57BL/6 MGI:4947682


Genotype
MGI:4840384
hm1
Allelic
Composition
Bco2tm1Dnp/Bco2tm1Dnp
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bco2tm1Dnp mutation (0 available); any Bco2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

growth/size/body

liver/biliary system
• whether fed a diet with tomato power or lycopene for 30 days, mice exhibit increased lycopene liver levels compared to in similarly treated wild-type mice
• in mice fed a diet supplemented with zeaxanthin
• mice fed a diet supplemented with zeaxanthin exhibit liver steatosis with large lipid droplets unlike wild-type mice
• hepatocytes from mice fed a diet supplemented with zeaxanthin exhibit impaired mitochondrial function with reduced oxygen consumption compared with hepatocytes from wild-type mice

homeostasis/metabolism
• whether fed a diet with tomato power or lycopene for 30 days, mice exhibit increased beta-carotene and lycopene tissue levels compared to in similarly treated wild-type mice
• whether fed a diet with tomato powder or lycopene for 30 days, mice exhibit increased lycopene serum levels compared to in similarly treated wild-type mice
• in mice fed a diet supplemented with zeaxanthin

immune system

endocrine/exocrine glands

hematopoietic system

adipose tissue
• mice fed a diet supplemented with zeaxanthin or lutein exhibit yellow coloring of adipose tissue compared with similarly treated wild-type mice

cellular
• hepatocytes from mice fed a diet supplemented with zeaxanthin exhibit impaired mitochondrial function with reduced oxygen consumption compared with hepatocytes from wild-type mice




Genotype
MGI:4947682
ht2
Allelic
Composition
Bco2tm1Dnp/Bco2+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bco2tm1Dnp mutation (0 available); any Bco2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• in mice fed a diet supplemented with zeaxanthin
• mice fed a diet supplemented with zeaxanthin exhibit liver steatosis with large lipid droplets unlike wild-type mice

homeostasis/metabolism
• in mice fed a diet supplemented with zeaxanthin





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory