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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sh2d1b1/Sh2d1b2tm1.1Cpt
targeted mutation 1.1, Cox Terhorst
MGI:4840396
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sh2d1b1/Sh2d1b2tm1.1Cpt/Sh2d1b1/Sh2d1b2tm1.1Cpt involves: BALB/cJ MGI:4840405
cx2
 		Sh2d1atm1Cpt/Sh2d1atm1Cpt
Sh2d1b1/Sh2d1b2tm1.1Cpt/Sh2d1b1/Sh2d1b2tm1.1Cpt 		involves: 129S4/SvJae * BALB/cJ MGI:4840408


Genotype
MGI:4840405
hm1
Allelic
Composition		 Sh2d1b1/Sh2d1b2tm1.1Cpt/Sh2d1b1/Sh2d1b2tm1.1Cpt
Genetic
Background		 involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1b1/Sh2d1b2tm1.1Cpt mutation (0 available); any Sh2d1b2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:166054 )
• in vivo clearance of RMAS/CD48+ tumors cells is impaired compared to in wild-type mice
• NK cell RMAS/CD48+, P815/CD84+, or B16/CD84+ tumors cell killing is impaired in vivo compared with wild-type cells
• NK cell P815/CD48+ tumors cell killing is abolished in vivo compared with wild-type cells
• NK cells are defective in anti-CD244 dependent killing of 51Cr-labeled P815 cells compared with wild-type mice
• NK cells kill anti-CD84-coated P815 and B16 cells less efficiently killed compared to wild-type cells
• however, clearance of RMAS/CD48- tumor cells is normal and NK cells efficiently kill YB2/0, YAC-1, and CHO cells
decreased interferon-gamma secretion ( J:166054 )
• in NK cells stimulated by CD244 with anti-CD244 antibodies
• however, IFN-gamma production by NK cells stimulated by anti-Ly49D or anti-NKG2D stimulation

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:166054 )
• in vivo clearance of RMAS/CD48+ tumors cells is impaired compared to in wild-type mice
• NK cell RMAS/CD48+, P815/CD84+, or B16/CD84+ tumors cell killing is impaired in vivo compared with wild-type cells
• NK cell P815/CD48+ tumors cell killing is abolished in vivo compared with wild-type cells
• NK cells are defective in anti-CD244 dependent killing of 51Cr-labeled P815 cells compared with wild-type mice
• NK cells kill anti-CD84-coated P815 and B16 cells less efficiently killed compared to wild-type cells
• however, clearance of RMAS/CD48- tumor cells is normal and NK cells efficiently kill YB2/0, YAC-1, and CHO cells




Genotype
MGI:4840408
cx2
Allelic
Composition		 Sh2d1atm1Cpt/Sh2d1atm1Cpt
Sh2d1b1/Sh2d1b2tm1.1Cpt/Sh2d1b1/Sh2d1b2tm1.1Cpt
Genetic
Background		 involves: 129S4/SvJae * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation (0 available); any Sh2d1a mutation (11 available)
Sh2d1b1/Sh2d1b2tm1.1Cpt mutation (0 available); any Sh2d1b2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:166054 )
• in vivo clearance of RMAS/CD48+ or P815/CD48+ tumors cells is impaired compared to in wild-type mice

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:166054 )
• in vivo clearance of RMAS/CD48+ or P815/CD48+ tumors cells is impaired compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory