All Phenotypes Trp53<tm1.1Xlu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm1.1Xlu
targeted mutation 1.1, Xin Lu
MGI:4840439

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1.1Xlu/Trp53^tm1.1Xlu	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * FVB/N	MGI:4840451
hm2	Trp53^tm1.1Xlu/Trp53^tm1.1Xlu	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4840450
cx3	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1.1Xlu/Trp53^tm1.1Xlu	involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4840452
cx4	Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1.1Xlu/Trp53^tm1.1Xlu	involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4840453

Allelic Composition	Trp53^tm1.1Xlu/Trp53^tm1.1Xlu
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1.1Xlu mutation (2 available); any Trp53 mutation (239 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:166152 )

N	• mice develop spontaneous tumor at normal rates

increased liver tumor incidence ( J:166152 )

• induced by irradiation, especially in black coated mice

increased lymphoma incidence ( J:166152 )

• induced by irradiation, especially in black coated mice

increased incidence of tumors by ionizing radiation induction ( J:166152 )

• mice begin to develop tumors at 25 weeks

• by 52, weeks 41% of mice develop tumors compared with 6% of similarly treated wild-type mice

• mice are more prone to induced lymphoma development compared with similarly treated wild-type mice

• black coated mice exhibit increased susceptibility to lymphomas and liver tumors compared with similarly treated black coated wild-type mice

liver/biliary system

liver hyperplasia ( J:166152 )

• irradiated mice are more susceptible to liver hyperplasia at late stages compared with similarly treated wild-type mice

increased liver tumor incidence ( J:166152 )

• induced by irradiation, especially in black coated mice

growth/size/body

liver hyperplasia ( J:166152 )

• irradiated mice are more susceptible to liver hyperplasia at late stages compared with similarly treated wild-type mice

Allelic Composition	Trp53^tm1.1Xlu/Trp53^tm1.1Xlu
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1.1Xlu mutation (2 available); any Trp53 mutation (239 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:166152 )

N	• mice exhibit normal survival

neoplasm

neoplasm ( J:166152 )

N	• mice develop spontaneous tumor at normal rates

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1.1Xlu/Trp53^tm1.1Xlu
Genetic Background	involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (193 available)
Trp53^tm1.1Xlu mutation (2 available); any Trp53 mutation (239 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:166152 )

• fewer than expected mice are present at E12.5, E13.5, and E14.5

• however, expected numbers of mice are present at E10.5

cellular

cellular phenotype ( J:166152 )

N	• mouse embryonic fibroblasts replicate normally in culture

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1.1Xlu/Trp53^tm1.1Xlu
Genetic Background	involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:166152 )

• fewer than expected mice are present at E10.5, E12.5, E13.5, and E14.5

embryo

abnormal embryo development ( J:166152 )

• mice are grossly abnormal

embryonic growth retardation ( J:166152 )

• in 4 of 6 mice at E12.5

growth/size/body

embryonic growth retardation ( J:166152 )

• in 4 of 6 mice at E12.5

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