All Phenotypes Rad21<tm1.1Kktk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rad21^tm1.1Kktk
targeted mutation 1.1, Kikue Tachibana-Konwalski
MGI:4840469

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rad21^tm1.1Kktk/Rad21^tm1.1Kktk	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4840515

Allelic Composition	Rad21^tm1.1Kktk/Rad21^tm1.1Kktk
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21^tm1.1Kktk mutation (0 available); any Rad21 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:166151 )

• fewer than expected mice are born

reproductive system

abnormal female meiosis ( J:166151 )

• TEV-treated oocytes fertilized by wild-type mice exhibit conversion of sister chromatids into single chromatids unlike in similarly treated wild-type zygotes

• however, sister centromere cohesion in unfertilized oocytes is normal

reduced male fertility ( J:166151 )

• male mice are not reliable breeders

cellular

abnormal female meiosis ( J:166151 )

• TEV-treated oocytes fertilized by wild-type mice exhibit conversion of sister chromatids into single chromatids unlike in similarly treated wild-type zygotes

• however, sister centromere cohesion in unfertilized oocytes is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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