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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfat5tm1.1Joar
targeted mutation 1.1, Jose Aramburu
MGI:4840524
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nfat5tm1.1Joar/Nfat5tm1.1Joar
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 * SJL MGI:4840544


Genotype
MGI:4840544
cn1
Allelic
Composition		 Nfat5tm1.1Joar/Nfat5tm1.1Joar
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfat5tm1.1Joar mutation (1 available); any Nfat5 mutation (67 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:148271 )
• T cells in a hypertonic solution exhibit reduced viability with a greater accumulation in G1 and G2/M phase, reduced DNA replication, and decreased expression of osmoprotective genes compared with similarly treated wild-type cells
• however, cell viability and cell cycle profile in isotonic conditions is normal

hematopoietic system
abnormal T cell physiology ( J:148271 )
• T cells in a hypertonic solution exhibit reduced viability with a greater accumulation in G1 and G2/M phase, reduced DNA replication, and decreased expression of osmoprotective genes compared with similarly treated wild-type cells
• however, cell viability and cell cycle profile in isotonic conditions is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory