Phenotypes associated with this allele

• Allele Symbol: Traf6^{tm2a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4840586
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Traf6^tm2a(EUCOMM)Wtsi/Traf6^tm2a(EUCOMM)Wtsi	C57BL/6N-Traf6^tm2a(EUCOMM)Wtsi/Wtsi	MGI:5701025
ht2	Traf6^tm2a(EUCOMM)Wtsi/Traf6^+	C57BL/6N-Traf6^tm2a(EUCOMM)Wtsi/Wtsi	MGI:5706115

Genotype
MGI:5701025

hm1

• Allelic Composition: Traf6^{tm2a(EUCOMM)Wtsi}/Traf6^{tm2a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Traf6^{tm2a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0530_9_H08

Data Sources

IMPC Data for Traf6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

persistent right dorsal aorta ( J:239583 )

DMDD

persistent right 6th pharyngeal arch artery ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

absent stapedial artery ( J:239583 )

DMDD

umbilical vein stenosis ( J:239583 )

DMDD

abnormal vitelline vein topology ( J:239583 )

DMDD

abnormal ductus venosus valve topology ( J:239583 )

DMDD

absent ductus venosus valve ( J:239583 )

DMDD

ductus venosus stenosis ( J:239583 )

DMDD

abnormal myocardium compact layer morphology ( J:239583 )

DMDD

abnormal coronary sinus connection ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

craniofacial

persistent right 6th pharyngeal arch artery ( J:239583 )

DMDD

abnormal stapes morphology ( J:239583 )

DMDD

digestive/alimentary system

intestinal/bowel diverticulum ( J:239583 )

DMDD

embryo

persistent right 6th pharyngeal arch artery ( J:239583 )

DMDD

umbilical vein stenosis ( J:239583 )

DMDD

abnormal vitelline vein topology ( J:239583 )

DMDD

abnormal Mullerian duct morphology ( J:239583 )

DMDD

abnormal Wolffian duct morphology ( J:239583 )

DMDD

endocrine/exocrine glands

dilated bile duct ( J:239583 )

DMDD

multiple persisting craniopharyngeal ducts ( J:239583 )

DMDD

hearing/vestibular/ear

absent stapedial artery ( J:239583 )

DMDD

abnormal stapes morphology ( J:239583 )

DMDD

abnormal endolymphatic sac topology ( J:239583 )

DMDD

homeostasis/metabolism

subcutaneous edema ( J:239583 )

DMDD

immune system

blood in lymph vessels ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

liver/biliary system

dilated bile duct ( J:239583 )

DMDD

herniated liver ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

muscle

abnormal myocardium compact layer morphology ( J:239583 )

DMDD

abnormal eye muscle morphology ( J:239583 )

DMDD

nervous system

abnormal brain morphology ( J:239583 )

DMDD

abnormal brain commissure morphology ( J:239583 )

DMDD

abnormal forebrain morphology ( J:239583 )

DMDD

multiple persisting craniopharyngeal ducts ( J:239583 )

DMDD

abnormal olfactory bulb morphology ( J:239583 )

DMDD

exencephaly ( J:239583 )

DMDD

thin hypoglossal nerve ( J:239583 )

DMDD

renal/urinary system

abnormal kidney morphology ( J:239583 )

DMDD

bifid ureter ( J:239583 )

DMDD

skeleton

abnormal stapes morphology ( J:239583 )

DMDD

vision/eye

abnormal eye muscle morphology ( J:239583 )

DMDD

abnormal optic cup morphology ( J:239583 )

DMDD

abnormal optic stalk morphology ( J:239583 )

DMDD

Genotype
MGI:5706115

ht2

• Allelic Composition: Traf6^{tm2a(EUCOMM)Wtsi}/Traf6⁺
• Genetic Background: C57BL/6N-Traf6^{tm2a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0530_9_H08

Data Sources

IMPC Data for Traf6

behavior/neurological

increased grip strength ( J:211773 )

♂

IMPC - WTSI