Phenotypes associated with this allele

• Allele Symbol: Trub2^{tm2a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4840623
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trub2^tm2a(EUCOMM)Wtsi/Trub2^tm2a(EUCOMM)Wtsi	C57BL/6N-Trub2^tm2a(EUCOMM)Wtsi/Wtsi	MGI:5701028
ht2	Trub2^tm2a(EUCOMM)Wtsi/Trub2^+	C57BL/6N-Trub2^tm2a(EUCOMM)Wtsi/Wtsi	MGI:5706116

Genotype
MGI:5701028

hm1

• Allelic Composition: Trub2^{tm2a(EUCOMM)Wtsi}/Trub2^{tm2a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Trub2^{tm2a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0530_8_C03

Data Sources

IMPC Data for Trub2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

embryonic lethality during organogenesis, complete penetrance ( J:261316 )

• lethality at E9.5-E10.5

Genotype
MGI:5706116

ht2

• Allelic Composition: Trub2^{tm2a(EUCOMM)Wtsi}/Trub2⁺
• Genetic Background: C57BL/6N-Trub2^{tm2a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0530_8_C03

Data Sources

IMPC Data for Trub2

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

IMPC - WTSI