Phenotypes associated with this allele

• Allele Symbol: Uggt1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4841374
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Uggt1^tm1a(KOMP)Wtsi/Uggt1^+	involves: C57BL/6N	MGI:6115490

Genotype
MGI:6115490

ht1

• Allelic Composition: Uggt1^{tm1a(KOMP)Wtsi}/Uggt1⁺
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0550_1_E05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal susceptibility to Picornaviridae infection ( J:244058 )

• after EVA71 (enterovirus A71) infection

decreased susceptibility to Picornaviridae infection ( J:244058 )

• significantly lower viral load 3 days post-infection

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:244058 )

• mild limb paralysis (versus severe in WT) 4 days post-infection

• first fatalities 10 days (versus 8 in WT) post-infection

• 90% survival rate (versus 0% in WT) 10 days post-infection

mortality/aging

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:244058 )

• mild limb paralysis (versus severe in WT) 4 days post-infection

• first fatalities 10 days (versus 8 in WT) post-infection

• 90% survival rate (versus 0% in WT) 10 days post-infection