Phenotypes associated with this allele

• Allele Symbol: Mymk^{tm1e(KOMP)Wtsi}
• Allele Name: targeted mutation 1e, Wellcome Trust Sanger Institute
• Allele ID: MGI:4841439
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mymk^tm1e(KOMP)Wtsi/Mymk^tm1e(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5538676

Genotype
MGI:5538676

hm1

• Allelic Composition: Mymk^{tm1e(KOMP)Wtsi}/Mymk^{tm1e(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0626_5_C12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:200444 )

• mice die between E17.5 and P7

muscle

abnormal muscle development ( J:200444 )

• at E17.5, mice lack differentiated muscle tissue in the trunk, limb and head

• however, specification of skeletal muscle lineage is normal

abnormal myoblast differentiation ( J:200444 )

• fusion-defective, non-viable with increased apoptotic nuclei

abnormal myoblast fusion ( J:200444 )

• fusion-defective myoblasts

behavior/neurological

paralysis ( J:200444 )

• at E17.5

skeleton

kyphosis ( J:200444 )

• at E17.5

cellular

increased apoptosis ( J:200444 )

• of myoblasts

abnormal myoblast differentiation ( J:200444 )

• fusion-defective, non-viable with increased apoptotic nuclei

abnormal myoblast fusion ( J:200444 )

• fusion-defective myoblasts