All Phenotypes Ankmy2<tm1a(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ankmy2^{tm1a(EUCOMM)Hmgu}
targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI:4841499

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ankmy2^{tm1a(EUCOMM)Hmgu}/Ankmy2^{tm1a(EUCOMM)Hmgu} Edil3^{Tg(Sox2-cre)1Amc}/0	involves: C57BL/6 * C57BL/6N * CBA	MGI:6489568

Allelic Composition	Ankmy2^{tm1a(EUCOMM)Hmgu}/Ankmy2^{tm1a(EUCOMM)Hmgu} Edil3^{Tg(Sox2-cre)1Amc}/0
Genetic Background	involves: C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankmy2^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Ankmy2 mutation (31 available)
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryonic neuroepithelial layer differentiation ( J:297055 )

• ventralized neural tube in E9.5 embryos (ventral cell types ectopically specified at expense of lateral and dorsal types) throughout rostrocaudal extent of spinal cord and hindbrain

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:297055 )

• embryos are arrested at 1012 somite stage (E8.5)

nervous system

abnormal embryonic neuroepithelial layer differentiation ( J:297055 )

• ventralized neural tube in E9.5 embryos (ventral cell types ectopically specified at expense of lateral and dorsal types) throughout rostrocaudal extent of spinal cord and hindbrain

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