Phenotypes associated with this allele

• Allele Symbol: Rtca^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4841792
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rtca^tm1a(EUCOMM)Hmgu/Rtca^tm1a(EUCOMM)Hmgu	involves: C57BL/6N	MGI:5806942

Genotype
MGI:5806942

hm1

• Allelic Composition: Rtca^{tm1a(EUCOMM)Hmgu}/Rtca^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:233466 )

• homozygotes are born at less than the expected Mendelian ratio

nervous system

nervous system phenotype ( J:233466 )

N • at 3 weeks after optic nerve crush, adult homozygotes show no differences in retinal ganglion cell (RGC) number and RGC axon morphology in contralateral uninjured retinas or in RGC survival in injured retinas relative to heterozygous or wild-type controls

enhanced central nervous system regeneration ( J:233466 )

• at 2 weeks after optic nerve crush, homozygotes operated at P35 show significantly more regenerating RGC axons up to 800 um distal to the lesion site, with some regenerating axons extending over 1.5 mm beyond the crush site, whereas heterozygous and wild-type controls show no obvious axon regrowth beyond the crush site

• at 3 weeks after optic nerve crush, homozygotes operated at 2-3 months of age show a milder phenotype with regenerating RGC axons up to 300 um distal to the lesion site; curving, turning and looping of axons indicates new axon growth, while the furthest distance traveled beyond the injury site is ~3.5 longer than in controls, and a large number of axons are found hundreds of microns beyond the ED1+ crush region unlike in controls