Phenotypes associated with this allele

• Allele Symbol: Npc1l1^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4842197
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npc1l1^tm1a(EUCOMM)Hmgu/Npc1l1^tm1a(EUCOMM)Hmgu	involves: C57BL/6 * C57BL/6N	MGI:5699003
hm2	Npc1l1^tm1a(EUCOMM)Hmgu/Npc1l1^tm1a(EUCOMM)Hmgu	involves: C57BL/6N	MGI:6192738

Genotype
MGI:5699003

hm1

• Allelic Composition: Npc1l1^{tm1a(EUCOMM)Hmgu}/Npc1l1^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: HEPD0668_3_C03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal cholesterol absorption ( J:226578 )

• much less cholesterol absorption in liver

homeostasis/metabolism

abnormal intestinal cholesterol absorption ( J:226578 )

• much less cholesterol absorption in liver

decreased circulating cholesterol level ( J:226578 )

• plasma cholesterol levels much reduced

Genotype
MGI:6192738

hm2

• Allelic Composition: Npc1l1^{tm1a(EUCOMM)Hmgu}/Npc1l1^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N

digestive/alimentary system

decreased intestinal cholesterol absorption ( J:263730 )

homeostasis/metabolism

decreased intestinal cholesterol absorption ( J:263730 )