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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Npc1l1tm1a(EUCOMM)Hmgu
targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI:4842197
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Npc1l1tm1a(EUCOMM)Hmgu/Npc1l1tm1a(EUCOMM)Hmgu involves: C57BL/6 * C57BL/6N MGI:5699003
hm2
Npc1l1tm1a(EUCOMM)Hmgu/Npc1l1tm1a(EUCOMM)Hmgu involves: C57BL/6N MGI:6192738


Genotype
MGI:5699003
hm1
Allelic
Composition
Npc1l1tm1a(EUCOMM)Hmgu/Npc1l1tm1a(EUCOMM)Hmgu
Genetic
Background
involves: C57BL/6 * C57BL/6N
Cell Lines HEPD0668_3_C03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npc1l1tm1a(EUCOMM)Hmgu mutation (0 available); any Npc1l1 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• much less cholesterol absorption in liver

homeostasis/metabolism
• much less cholesterol absorption in liver
• plasma cholesterol levels much reduced




Genotype
MGI:6192738
hm2
Allelic
Composition
Npc1l1tm1a(EUCOMM)Hmgu/Npc1l1tm1a(EUCOMM)Hmgu
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npc1l1tm1a(EUCOMM)Hmgu mutation (0 available); any Npc1l1 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system

homeostasis/metabolism





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory