All Phenotypes Fbxo7<tm1a(EUCOMM)Wtsi> MGI Mouse

thymus atrophy ( J:272313 )

• mice show severe thymic atrophy, with the thymus virtually undetectable by 10 weeks of age

thymus hypoplasia ( J:272313 )

• mice show a significant reduction in total thymus cell number at 8 weeks of age

enlarged spleen ( J:272313 )

• mice exhibit splenomegaly suggestive of compensatory extramedullary hematopoiesis

increased spleen weight ( J:272313 )

abnormal T cell differentiation ( J:272313 )

increased double-negative T cell number ( J:272313 )

• mice show an increase in immature CD4/CD8 double negative T cells in the thymus at 8 weeks of age

extramedullary hematopoiesis ( J:272313 )

• mice show extramedullary erythropoiesis in spleen with a significant increase in the % of more immature (CD71+) cells

anemia ( J:272313 )

• mice exhibit regenerative anemia associated with a shorter erythrocyte half-life

hyperchromic macrocytic anemia ( J:272313 )

increased erythroblast number ( J:272313 )

• mice show a significant increase in splenic erythroblast number at 15-17 weeks of age

decreased erythrocyte cell number ( J:272313 )

• erythrocyte number is significantly reduced at 16 weeks of age

decreased hematocrit ( J:272313 )

decreased hemoglobin content ( J:272313 )

• hemoglobin level is significantly reduced at 16 weeks of age

increased mean corpuscular hemoglobin concentration ( J:272313 )

increased mean corpuscular volume ( J:272313 )

increased red blood cell distribution width ( J:272313 )

anisocytosis ( J:272313 )

abnormal effector T cell number ( J:272313 )

• remaining circulating T cells exhibit an altered phenotype with an increase in T cells expressing high levels of CD44 and low levels of L selectin (CD62L), representing an effector memory status

increased memory T cell number ( J:272313 )

• mice show a significant increase of activated/memory T cells in spleen

increased effector memory CD4-positive, alpha-beta T cell number ( J:272313 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:272313 )

decreased T cell number ( J:272313 )

• mice show a significant reduction of T cells in peripheral blood and spleen, both in the CD4+ and CD8+ subsets

decreased CD4-positive, alpha-beta T cell number ( J:272313 )

decreased CD8-positive, alpha-beta T cell number ( J:272313 )

increased activated T cell number ( J:272313 )

• mice show a significant increase of activated/memory T cells in spleen

abnormal reticulocyte cell number ( J:272313 )

• mice show a significant increase in splenic reticulocyte number at 15-17 weeks of age

reticulocytosis ( J:272313 )

• circulating reticulocyte number is significantly increased at 15-17 weeks of age

increased erythrocyte clearance ( J:272313 )

• in vivo half-life of erythrocytes is significantly shorter than that in wild-type controls

thymus atrophy ( J:272313 )

• mice show severe thymic atrophy, with the thymus virtually undetectable by 10 weeks of age

thymus hypoplasia ( J:272313 )

• mice show a significant reduction in total thymus cell number at 8 weeks of age

enlarged spleen ( J:272313 )

• mice exhibit splenomegaly suggestive of compensatory extramedullary hematopoiesis

increased spleen weight ( J:272313 )

abnormal T cell differentiation ( J:272313 )

increased double-negative T cell number ( J:272313 )

• mice show an increase in immature CD4/CD8 double negative T cells in the thymus at 8 weeks of age

abnormal effector T cell number ( J:272313 )

• remaining circulating T cells exhibit an altered phenotype with an increase in T cells expressing high levels of CD44 and low levels of L selectin (CD62L), representing an effector memory status

increased memory T cell number ( J:272313 )

• mice show a significant increase of activated/memory T cells in spleen

increased effector memory CD4-positive, alpha-beta T cell number ( J:272313 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:272313 )

decreased T cell number ( J:272313 )

• mice show a significant reduction of T cells in peripheral blood and spleen, both in the CD4+ and CD8+ subsets

decreased CD4-positive, alpha-beta T cell number ( J:272313 )

decreased CD8-positive, alpha-beta T cell number ( J:272313 )

increased activated T cell number ( J:272313 )

• mice show a significant increase of activated/memory T cells in spleen

increased susceptibility to bacterial infection ( J:272313 )

• following systemic infection with Salmonella typhimurium, mice exhibit exacerbated weight loss and splenomegaly, evidence of hepatocyte necrosis surrounded by inflammatory cell infiltration, a trend towards increased plasma levels of alanine aminotransferase and aspartate aminotransferase, higher plasma levels of amylase and lipase, and a striking increase in plasma ferritin levels at day 6 post infection relative to similarly infected wild-type controls

increased susceptibility to bacterial infection induced morbidity/mortality ( J:272313 )

• mice exhibit increased morbidity after infection with Salmonella typhimurium and need to be sacrificed prior to day 11 post infection, whereas wild-type controls survive to day 15

increased circulating bilirubin level ( J:272313 )

• plasma bilirubin concentration is significantly increased at 15-17 weeks of age

decreased circulating iron level ( J:272313 )

• plasma iron level is significantly decreased at 15-17 weeks of age

immotile sperm ( J:272313 )

• epididymal spermatozoa show no motility

decreased testis weight ( J:272313 )

• testis weight is significantly reduced at 18-19 weeks of age

abnormal spermatogenesis ( J:272313 )

• males exhibit impaired spermatogenesis with spermatid arrest and markedly reduced spermatozoa formation at 8 weeks of age

oligozoospermia ( J:272313 )

• males exhibit a significantly reduced number of spermatozoa in the epididymis at 12-14 weeks of age

teratozoospermia ( J:272313 )

• epididymal spermatozoa are rare and show an abnormal morphology

arrest of spermiogenesis ( J:272313 )

male infertility ( J:272313 )

• male mice are infertile with no litters resulting from matings with known fertile females

oligozoospermia ( J:272313 )

• males exhibit a significantly reduced number of spermatozoa in the epididymis at 12-14 weeks of age

teratozoospermia ( J:272313 )

• epididymal spermatozoa are rare and show an abnormal morphology

immotile sperm ( J:272313 )

• epididymal spermatozoa show no motility

behavior/neurological phenotype ( J:272313 )

N	• mice show no evidence of neurological (Parkinsons-like) symptoms

mortality/aging ( J:272313 )

N	• mice are born at the expected Mendelian ratio and show a normal lifespan

increased susceptibility to bacterial infection induced morbidity/mortality ( J:272313 )

• mice exhibit increased morbidity after infection with Salmonella typhimurium and need to be sacrificed prior to day 11 post infection, whereas wild-type controls survive to day 15

thymus atrophy ( J:272313 )

• mice show severe thymic atrophy, with the thymus virtually undetectable by 10 weeks of age

thymus hypoplasia ( J:272313 )

• mice show a significant reduction in total thymus cell number at 8 weeks of age

decreased testis weight ( J:272313 )

• testis weight is significantly reduced at 18-19 weeks of age

enlarged spleen ( J:272313 )

• mice exhibit splenomegaly suggestive of compensatory extramedullary hematopoiesis

increased spleen weight ( J:272313 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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