Phenotypes associated with this allele

• Allele Symbol: Fam13b^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4842400
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fam13b^tm1a(EUCOMM)Wtsi/Fam13b^tm1a(EUCOMM)Wtsi	C57BL/6-Fam13b^tm1a(EUCOMM)Wtsi	MGI:7783616

Genotype
MGI:7783616

hm1

• Allelic Composition: Fam13b^{tm1a(EUCOMM)Wtsi}/Fam13b^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6-Fam13b^{tm1a(EUCOMM)Wtsi}
• Cell Lines: EPD0637_4_A08

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:358633 )

N • young mice exhibit normal basal surface ECGs with no detectable spontaneous arrhythmias

N • at 1 year of age, male mice show normal ejection fraction and left ventricular mass, as assessed by echocardiography; postmortem analysis showed normal heart weight and heart appearance and histology in both sexes, with no abundant fibrosis in the ventricular or atrial myocardium

prolonged P wave ( J:358633 )

♂ • at 1 year of age, male, but not female, mice show significantly longer P-wave duration than wild-type controls; the median duration for the male P-wave is 34% longer

prolonged QRS complex duration ( J:358633 )

♂ • at 1 year of age, male, but not female, mice show significantly longer QRS duration than wild-type controls

prolonged QT interval ( J:358633 )

♂ • at 1 year of age, male, but not female, mice show significantly longer QT and corrected QT intervals than wild-type controls; the median duration for the male corrected QT is 29% longer

♂ • however, the male RR interval is normal

increased response of heart to induced stress ( J:358633 )

• under isoproterenol stress conditions, females are significantly more susceptible to induction of atrial fibrillation (AF) than wild-type controls, as quantified by the % of mice with AF incidents

• AF is induced more frequently in both males and females under basal conditions, and in females under isoproterenol stimulation, as quantified per pacing trial

• some instances of ventricular arrhythmias (VA) due to premature ventricular contractions are also observed; VA is induced more frequently in males under isoproterenol stimulation, and in both sexes and conditions combined

homeostasis/metabolism

increased response of heart to induced stress ( J:358633 )

• under isoproterenol stress conditions, females are significantly more susceptible to induction of atrial fibrillation (AF) than wild-type controls, as quantified by the % of mice with AF incidents

• AF is induced more frequently in both males and females under basal conditions, and in females under isoproterenol stimulation, as quantified per pacing trial

• some instances of ventricular arrhythmias (VA) due to premature ventricular contractions are also observed; VA is induced more frequently in males under isoproterenol stimulation, and in both sexes and conditions combined