All Phenotypes Katnal2<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Katnal2^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4842422

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Katnal2^{tm1a(EUCOMM)Wtsi}/Katnal2^{tm1a(EUCOMM)Wtsi}	C57BL/6N-Katnal2^{tm1a(EUCOMM)Wtsi}	MGI:6274235
ht2	Katnal2^m1Anu/Katnal2^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6J * C57BL/6N	MGI:6274238

Allelic Composition	Katnal2^{tm1a(EUCOMM)Wtsi}/Katnal2^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Katnal2^{tm1a(EUCOMM)Wtsi}
Cell Lines	EPD0656_4_A03

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Katnal2^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Katnal2 mutation (201 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Spermatogenic defects in Katnal2^{tm1a(EUCOMM)Wtsi}/Katnal2^{tm1a(EUCOMM)Wtsi} mice

reproductive system

multinucleated giant male germ cells ( J:250115 )

• multinucleated symplasts are frequently observed in the seminiferous epithelium

abnormal seminiferous tubule epithelium morphology ( J:250115 )

• multinucleated symplasts are frequently observed in the seminiferous epithelium

abnormal spermatogenesis ( J:250115 )

abnormal spermatid morphology ( J:250115 )

• elongating spermatids frequently exhibit abnormal nuclear morphology

abnormal spermiation ( J:250115 )

• total epididymal sperm content is reduced by 96.8% relative to wild-type controls; however, testis weight and daily sperm output in the testes are normal, indicating a massive failure of spermiation

• retained elongated spermatids are often observed in stage IX seminiferous tubules, unlike in wild-type controls

male infertility ( J:250115 )

• males are sterile and exhibit an apparently identical male fertility phenotype to that observed in Katnal2^m1Anu homozygotes

cellular

abnormal spermatid morphology ( J:250115 )

• elongating spermatids frequently exhibit abnormal nuclear morphology

multinucleated giant male germ cells ( J:250115 )

• multinucleated symplasts are frequently observed in the seminiferous epithelium

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:250115 )

• multinucleated symplasts are frequently observed in the seminiferous epithelium

Allelic Composition	Katnal2^m1Anu/Katnal2^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6J * C57BL/6N
Cell Lines	EPD0656_4_A03

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Katnal2^m1Anu mutation (1 available); any Katnal2 mutation (201 available)
Katnal2^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Katnal2 mutation (201 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Spermiation and spermatid defects in Katnal2^m1Anu/Katnal2^{tm1a(EUCOMM)Wtsi} mice

reproductive system

abnormal spermatid morphology ( J:250115 )

• elongating spermatids frequently exhibit abnormal nuclear (club shaped) morphology

multinucleated giant male germ cells ( J:250115 )

• multinucleated symplasts are frequently observed in the seminiferous epithelium

abnormal seminiferous tubule epithelium morphology ( J:250115 )

• multinucleated symplasts are frequently observed in the seminiferous epithelium

abnormal spermiation ( J:250115 )

• total epididymal sperm content is reduced by 94.5% relative to wild-type controls; however, testis weight and daily sperm output in the testes are normal, indicating a massive failure of spermiation

• retained elongated spermatids are often observed in stage IX seminiferous tubules, unlike in wild-type controls

male infertility ( J:250115 )

• males are sterile and exhibit an apparently identical male fertility phenotype to that observed in Katnal2^m1Anu homozygotes

cellular

abnormal spermatid morphology ( J:250115 )

• elongating spermatids frequently exhibit abnormal nuclear (club shaped) morphology

multinucleated giant male germ cells ( J:250115 )

• multinucleated symplasts are frequently observed in the seminiferous epithelium

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:250115 )

• multinucleated symplasts are frequently observed in the seminiferous epithelium

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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