Phenotypes associated with this allele

• Allele Symbol: Tmem18^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4842746
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem18^tm1a(EUCOMM)Wtsi/Tmem18^tm1a(EUCOMM)Wtsi	C57BL/6N-Tmem18^tm1a(EUCOMM)Wtsi	MGI:6117720

Genotype
MGI:6117720

hm1

• Allelic Composition: Tmem18^{tm1a(EUCOMM)Wtsi}/Tmem18^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Tmem18^{tm1a(EUCOMM)Wtsi}
• Cell Lines: EPD0790_2_C08

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body fat mass ( J:244315 )

♂ • in male, but not female, mice fed standard chow or a high-fat diet

increased lean body mass ( J:244315 )

♂ • in male, but not female, mice fed standard chow or a high-fat diet

increased body weight ( J:244315 )

♂ • by 14 weeks in male, but not female, mice fed standard chow or a high-fat diet

increased susceptibility to diet-induced obesity ( J:244315 )

♂ • in male, but not female, mice fed a high-fat diet

adipose tissue

increased body fat mass ( J:244315 )

♂ • in male, but not female, mice fed standard chow or a high-fat diet

increased brown adipose tissue mass ( J:244315 )

♂ • at 16 weeks in male mice fed standard chow or a high-fat diet

increased gonadal fat pad weight ( J:244315 )

♂ • by 14 weeks in male, but not female, mice fed standard chow or a high-fat diet

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:244315 )

♂ • in male, but not female, mice fed a high-fat diet

increased energy expenditure ( J:244315 )

♂ • in male mice fed a high-fat diet

behavior/neurological

increased food intake ( J:244315 )

♂ • in male, but not female, mice fed a high-fat diet