Phenotypes associated with this allele

• Allele Symbol: Notch4^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4842905
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch4^tm1(KOMP)Vlcg/Notch4^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5790678
ht2	Notch4^tm1(KOMP)Vlcg/Notch4^+	involves: C57BL/6NTac	MGI:5790679

Genotype
MGI:5790678

hm1

• Allelic Composition: Notch4^{tm1(KOMP)Vlcg}/Notch4^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:212472 )

N • homozygotes are born at expected Mendelian ratios and are viable, suggesting that embryonic angiogenesis is normal

cardiovascular system

abnormal retina vasculature morphology ( J:212472 )

• P5 retinas show a 13.0% reduction in the area covered by the vascular plexus relative to wild-type retinas, indicating a delay in retinal angiogenesis

• at P5, growth of the retinal vascular plexus is delayed to a lesser extent than in mice homozygous for Notch4^tm1Grid allele

• P5 retinas show an insignificant (9.8%) reduction in total vessel length, and vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal

vision/eye

abnormal retina vasculature morphology ( J:212472 )

• P5 retinas show a 13.0% reduction in the area covered by the vascular plexus relative to wild-type retinas, indicating a delay in retinal angiogenesis

• at P5, growth of the retinal vascular plexus is delayed to a lesser extent than in mice homozygous for Notch4^tm1Grid allele

• P5 retinas show an insignificant (9.8%) reduction in total vessel length, and vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal

Genotype
MGI:5790679

ht2

• Allelic Composition: Notch4^{tm1(KOMP)Vlcg}/Notch4⁺
• Genetic Background: involves: C57BL/6NTac

cardiovascular system

abnormal retina vasculature morphology ( J:212472 )

• P5 retinas show a 10.9% reduction in the area covered by the vascular plexus relative to wild-type retinas

abnormal retina blood vessel morphology ( J:212472 )

• P5 retinas show a significant (9.7%) reduction in total vessel length relative to wild-type retinas

• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal

vision/eye

abnormal retina vasculature morphology ( J:212472 )

• P5 retinas show a 10.9% reduction in the area covered by the vascular plexus relative to wild-type retinas

abnormal retina blood vessel morphology ( J:212472 )

• P5 retinas show a significant (9.7%) reduction in total vessel length relative to wild-type retinas

• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal