Phenotypes associated with this allele

• Allele Symbol: Lgals8^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4842980
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lgals8^tm1(KOMP)Vlcg/Lgals8^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5824822

Genotype
MGI:5824822

hm1

• Allelic Composition: Lgals8^{tm1(KOMP)Vlcg}/Lgals8^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 14305A-F8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lymphangiogenesis and severity of herpes simplex virus-induced keratitis and suture-induced inflammatory lymphangiogenesis is reduced in Lgals8^{tm1(KOMP)Vlcg}/Lgals8^{tm1(KOMP)Vlcg} mice

immune system

abnormal lymphangiogenesis ( J:235778 )

• in a model of herpes simplex virus keratitis, corneal pathological lymphangiogenesis induced by HSV-1 infection is significantly reduced relative to that in similarly-infected wild-type controls

• on day 7 post corneal suture placement, the extent of suture-induced inflammatory lymphangiogenesis is significantly reduced relative to that in similarly-treated wild-type controls

• in corneal micropocket assays, corneas implanted with VEGF-C pellets show significantly reduced VEGF-C-induced lymphangiogenesis, as quantified by the lymphatic vessel area on day 7 post-surgery

• however, untreated mice show no obvious defects in lymphatic vessel development

decreased susceptibility to Herpesvirales infection ( J:235778 )

• on day 8 post corneal HSV-1 infection (keratitis), mice exhibit significantly lower corneal opacity scores and reduced pathological lymphangiogenesis relative to similarly-infected wild-type controls