Phenotypes associated with this allele

• Allele Symbol: Slc38a5^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4843107
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc38a5^tm1(KOMP)Vlcg/Slc38a5^tm1(KOMP)Vlcg	C57BL/6-Slc38a5^tm1(KOMP)Vlcg	MGI:6120553
cx2	Gcgr^tm1Mjch/Gcgr^tm1Mjch Slc38a5^tm1(KOMP)Vlcg/Slc38a5^tm1(KOMP)Vlcg	involves: 129/Sv * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL	MGI:6120555

Genotype
MGI:6120553

hm1

• Allelic Composition: Slc38a5^{tm1(KOMP)Vlcg}/Slc38a5^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL/6-Slc38a5^{tm1(KOMP)Vlcg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:251829 )

N • pancreatic beta cell mass and number of islets per pancreas area

N • pancreatic beta cell mass and number of islets per pancreas area following glucagon receptor (Gcgr) antibody administration

abnormal pancreatic alpha cell morphology ( J:251829 )

• 50% reduced hyperplasia following glucagon receptor (Gcgr) antibody administration compared to wild-type

• alpha cell size following glucagon receptor (Gcgr) antibody administration

• alpha cell mass and size

growth/size/body

growth/size/body region phenotype ( J:251829 )

N • body, pancreas and liver weights

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:251829 )

N • blood glucose level, plasma amino acids, glucagon and insulin levels, oral glucose tolerance and insulin sensitivity, pancreas glucagon and insulin levels

Genotype
MGI:6120555

cx2

• Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch; Slc38a5^{tm1(KOMP)Vlcg}/Slc38a5^{tm1(KOMP)Vlcg}
• Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:251829 )

N • pancreatic beta cell mass

abnormal pancreatic alpha cell morphology ( J:251829 )

• almost 50% reduced hyperplasia compared to Gcgr single knockout mice

• reduced cell size compared to Gcgr single knockout mice

pancreatic islet hyperplasia ( J:251829 )

• increase per pancreas area compared to wild-type, but lower increase than Gcgr single knockout mice

homeostasis/metabolism

abnormal circulating amino acid level ( J:251829 )

• increased in plasma

hypoglycemia ( J:251829 )

increased circulating glucagon level ( J:251829 )

decreased circulating insulin level ( J:251829 )