All Phenotypes Pkd2<tm1.1Tjwt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pkd2^tm1.1Tjwt
targeted mutation 1.1, Terry J Watnick
MGI:4843126

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pkd2^tm1.1Tjwt/Pkd2^tm1.1Tjwt	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * SJL	MGI:4843162
cn2	Pkd2^tm1.1Tjwt/Pkd2^tm1.2Tjwt Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4843164
cn3	Pkd2^tm1.1Tjwt/Pkd2^tm1.1Tjwt Tg(Tek-cre)1Ywa/0	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * SJL	MGI:4843169

Allelic Composition	Pkd2^tm1.1Tjwt/Pkd2^tm1.1Tjwt
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2^tm1.1Tjwt mutation (1 available); any Pkd2 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:165114 )

• mice are phenotypically normal

Allelic Composition	Pkd2^tm1.1Tjwt/Pkd2^tm1.2Tjwt Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Pkd2^tm1.1Tjwt mutation (1 available); any Pkd2 mutation (85 available)
Pkd2^tm1.2Tjwt mutation (0 available); any Pkd2 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:165114 )

endocrine/exocrine glands

pancreas cyst ( J:165114 )

cardiovascular system

dextrocardia ( J:165114 )

homeostasis/metabolism

edema ( J:165114 )

• in neonates

growth/size/body

pancreas cyst ( J:165114 )

kidney cyst ( J:165114 )

situs inversus ( J:165114 )

renal/urinary system

kidney cyst ( J:165114 )

Allelic Composition	Pkd2^tm1.1Tjwt/Pkd2^tm1.1Tjwt Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2^tm1.1Tjwt mutation (1 available); any Pkd2 mutation (85 available)
Tg(Tek-cre)1Ywa mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:165114 )

• fewer than expected mice are recovered in the perinatal period

prenatal lethality, incomplete penetrance ( J:165114 )

• fewer than expected mice are recovered between E8.5 and E15.5

embryo

abnormal placenta vasculature ( J:165114 )

• mice exhibit dilation of maternal vasculature in the placenta unlike in wild-type mice

• fewer fetal vessels and investing pericytes are present in the placenta compared to in wild-type mice

• fewer branched placental vessels are observed compared to in wild-type mice

• however, placental layer size is normal

cardiovascular system

abnormal placenta vasculature ( J:165114 )

• mice exhibit dilation of maternal vasculature in the placenta unlike in wild-type mice

• fewer fetal vessels and investing pericytes are present in the placenta compared to in wild-type mice

• fewer branched placental vessels are observed compared to in wild-type mice

• however, placental layer size is normal

hemorrhage ( J:165114 )

• in a small fraction of mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:165114 )

N	• unlike in null mice, no edema is observed

polyhydramnios ( J:165114 )

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